The Government of Canada invests over $21M in innovative health research

Minister Philpott visits Laval University to meet with top researchers who have joined forces in the fight against HIV/AIDS and other diseases

QUÉBEC CITY, Aug. 21, 2017 /CNW/ - Researchers from Laval University and from across the country are working hard to create new scientific knowledge and tackle some of today's most pressing health issues that affect Canadians.

Today, the honourable Jane Philpott, Minister of Health, was at the CHU de Québec – Laval University Research Centre, to highlight a total investment of over $21M in cutting-edge research from the Canadian Institutes of Health Research.

Twelve researchers, including two from Laval University, received $2.9M to undertake innovative biomedical and clinical HIV vaccine research projects. Furthermore, Dr. Gary Kobinger, renowned for his work on the world's first effective vaccine against the Ebola virus, received a $3.9M grant to work on a vaccine to prevent HIV. The Minister took the opportunity to commend a further 18 researchers from Laval University who received a total of $14.4M in funding to tackle conditions such as heart disease, asthma and cancer.

The Minister was joined by her Parliamentary Secretary, Joël Lightbound. During their visit, they had an opportunity to meet with researchers to learn about their projects, and participate in a lab tour.

Quotes

"It's always a great experience to meet with researchers who are at the forefront of creating the new scientific knowledge needed to treat illnesses, eradicate viruses like HIV, and improve quality of life. The researchers working at Laval University are a source of great inspiration to Canadians. We all benefit from their hard work."
Jane Philpott
Minister of Health 

"The brilliant researchers working at the CHU de Québec – Laval University Research Centre have helped put Laval University on the international stage for leading-edge scientific research. The projects funded through CIHR will improve the human condition by tackling some of the most devastating health issues of our time. The researchers being celebrated today should be very proud of what they are accomplishing."  
Joël Lightbound
Parliamentary Secretary to the Minister of Health
Member of Parliament for Louis-Hébert

"I wish to congratulate the most recent recipients of CIHR funding working at CHU de Québec – Laval University Research Centre. Each of your projects shows tremendous potential for adding to the scientific knowledge we have about conditions such as asthma, heart disease, cancer and HIV/AIDS. Thank you for your contributions to health research and to building a healthier Canada."
Dr. Marc Ouellette
Scientific Director, CIHR Institute of Infection and Immunity

Quick Facts

  • CIHR has provided 12 grants in the area of biomedical and clinical HIV/AIDS research for a total investment of $2.9M. These grants are designed to support cutting-edge biomedical and clinical research related to the development of an HIV vaccine.
  • CIHR has awarded a grant of $3.9M to Laval University's Dr. Gary Kobinger to work towards developing a safe and effective HIV vaccine.
  • Today's announced research projects are partly funded by the CIHR HIV/AIDS Research Initiative, which is the research arm of the Federal Initiative to Address HIV/AIDS in Canada. It invests $21 million each year to support research, capacity building and knowledge translation activities in four key areas: Biomedical and clinical research; Health services and population health research; Community-Based Research; and the CIHR Canadian HIV Trials Network (CTN).
  • Project Grants are designed to support researchers at any career stage build and conduct health research and knowledge translation projects covering a range of areas, from discovery science and clinical research to strengthening the health care system and examining the social determinants of health. In the most recent Project Grant competition, CIHR provided $14.4M to support 18 researchers affiliated at Laval University.

Related Products
Backgrounder – Biomedical and clinical HIV/AIDS research grants
Backgrounder – Operating Grant: Optimizing the VSV Vector towards an HIV Vaccine
Backgrounder – Project Grants
Backgrounder – Dr. Kobinger's research
CIHR HIV/AIDS Initiative
Federal Initiative to Address HIV/AIDS in Canada

At the Canadian Institutes of Health Research (CIHR) we know that research has the power to change lives. As Canada's health research investment agency, we collaborate with partners and researchers to support the discoveries and innovations that improve our health and strengthen our health care system.

Backgrounder

Operating Grant: Innovative Biomedical and Clinical HIV/AIDS Research

Through new CIHR funding, researchers will undertake innovative biomedical and clinical HIV vaccine research projects in new areas of investigation or take previous discoveries in new directions; promote the development and testing of novel HIV vaccine research tools and methodologies; and support high-risk HIV vaccine research projects with the potential for high impact, breakthrough and/or transformative advances.       

A total of ten researchers and two new investigators from across the country were awarded $2.9M dollars for the following projects:

 

Researcher

Institution

Project Title

Amount

Dr. Petronela Ancuta

Centre hospitalier de l'Université de Montréal (CHUM)

 

Targeting mTOR to restore mucosal immunity toward remission in HIV-infected individuals

$250,000

Dr. Eric Arts

University of Western Ontario

 

Developing the ACT-VEC as an HIV therapeutic vaccine and cure approach

$250,000

Dr. Dimitrios Dikeakos

University of Western Ontario

 

Nef Inhibitors as Adjuvants Towards a Cure

$247,755

Dr. Jérôme Estaquier

Université Laval

 

Role of follicular CD8 T cells in the control of HIV/SIV mucosal immunity.

 

$250,000

Dr. Daniel E Kaufmann

Centre hospitalier de l'Université de Montréal (CHUM)

 

Influence of pre-existing HIV cross-reactive CD4 T cells on vaccine responses to new Env immunogens

$249,994

Dr. Charu Kaushic

McMaster University

 

Improving vaginal health to decrease biological risk of HIV-1 infection in Canadian ACB women

 

$250,000

Dr. Denis Leclerc

Université Laval

 

Adjuvantization of SIV antigens using a novel toll like receptor 7 (TLR7) agonist: A proof of concept in non-human primate.

 

$250,000

Dr. Lyle R Mckinnon

University of Manitoba

 

Impact of Vedolizumab on immune cell homing to the female reproductive and gastrointestinal mucosa

 

$249,460

Dr. Mario A Ostrowski

University of Toronto

 

Developing a Novel Modular Nanoparticle Vaccine Strategy to Induce Durable Systemic and Mucosal HIV Envelope Specific Antibodies

 

$250,000

Dr. Jean-Pierre Routy

Research Institute of the McGill University Health Centre

 

Locking out HIV from CD4 T cells: A pilot study of the impact of anti a4b7 antibody (vedolizumab) on viral control following analytical treatment interruption

 

$247,650

Adam Burgener

University of Manitoba

Mechanisms of metaproteome factors in HIV infection risk in young women

$249,888

Ruey-Chyi

University of Manitoba

Elucidating the role of cell homing pathways in controlling endothelial cell-mediated enhancement of resting CD4+ T cell infection by HIV

$206,600

 

Backgrounder

Operating Grant: Optimizing the VSV Vector towards an HIV Vaccine

 

Researcher

Institution

Project Title

Amount

Dr. Gary Kobinger

Laval University

 

Development of a safe, effective and clinically acceptable VSV-based HIV vaccine

$3,997, 503

 

Backgrounder

Project Grants

Project Grants are designed to support researchers at any career stage build and conduct health research and knowledge translation projects covering a range of areas, from discovery science and clinical research to strengthening the health care system and examining the social determinants of health.

In the most recent Project Grants competition, CIHR provided $14.4M to support 18 researchers at Laval University.

 

Researcher

Project

Funding Amount

Dr. Patrick Archambault


Supporting the creation of a LEARNing INteGrated health system to mobilize context-adapted knowledge with a Wiki platform to Improve the transitions of frail Seniors from from hospitals and emergency Departments to the cOMmunity: the LEARNING WISDOM Phase II scale-up project

 

$1.47M

Dr. Jean-François Bilodeau


Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia

 

$662,000

Dr. Elyse Bissonnette


CD200 dysregulation in asthma: potential for therapy?

 

$643,000

Dr. Mohamed Chahine


Investigating the role of gating pore current in cardiac arrhythmias associated with dilated cardiomyopathy

 

$1.03M

Dr. Paul De Koninck


Optical nanoscopy of cytoskeletal and synaptic remodeling in neurons

 

$784,000

Dr. Sabine Elowe

 

Towards a comprehensive model of Spindle Assembly Checkpoint silencing

 

$536,000

Dr. Amélie Fradet-Turcotte

 

 

Defining the molecular basis of chemoradiation sensitivity in HPV+ head and neck cancers.

 

$696,000

Dr. Chantal Guillemette

 

Function of the glucuronosyltransferase pathway in chronic lymphocytic leukemia

 

$639,000

Dr. Samer Hussein

 

The role of long non-coding RNAs in defining pluripotent stem cell states

 

$799,000

Dr. Mathieu Laplante

 

Molecular mechanisms of adipose tissue development

 

$696,000

Dr. Jean-Yves Masson

 

Roles of the tumor suppressor PALB2 at the crossroads of DNA double-strand break repair and synthetic lethal strategies

 

$968,000

Dr. Donald Poirier

 

Développement d'un traitement sélectif de l'endométriose : Étude du potentiel du premier inhibiteur irréversible de la 17beta-HSD1 chez le primate

 

$363,000

Dr. Armen Saghatelyan

 

Deciphering the role of autophagy in neuronal migration and maturation

 

$991,000

Dr. François Gros-Louis

Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent

 

$952,425

Dr. Sébastien Hébert

microRNA-132: from underlying mechanism of neurodegeneration to therapeutic application in Huntington's disease

 

$573,750

Dr. Michel G  Maziade

Intercepting the "childhood risk syndrome" of schizophrenia and mood disorders along the developmental trajectory: A preclinical staging of children and adolescents at genetic risk

 

$852,975

Dr. Thomas Moss

Mechanism of Ribosomal RNA Gene Silencing and Its Roles in Pluripotency and Cancer

 

$1,074,060

Dr.  Martin Parent 

La modulation des ganglions de la base par les afférences neurochimiques du tronc cérébral: implication dans la physiopathologie des troubles du mouvement

 

$738,225

 

SOURCE Canadian Institutes of Health Research

For further information: Andrew MacKendrick, Office of the Honourable Jane Philpott, Minister of Health, 613-957-0200; Media Relations, Canadian Institutes of Health Research, 613-941-4563, mediarelations@cihr-irsc.gc.ca

RELATED LINKS
http://www.cihr-irsc.gc.ca

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