• Resources
  • Blog
  • Journalists
  • Webcasts
  • Data Privacy
  • Français
  • my CNW 
    • Login
    • Register
  • Client Login 
    • Online Member Centre
    • Next Gen Communications Cloud
    • Cision Communications Cloud®
  • Sign Up
  • Send a Release
Cision Canada
  • News
  • Products
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
Advanced Search
  • News in Focus
      • Browse News Releases

      • All News Releases
      • All Public Company
      • News Releases Overview

      • Multimedia Gallery

      • All Multimedia
      • All Photos
      • All Videos
      • Multimedia Gallery Overview

      • Trending Topics

      • All Trending Topics
  • Business
      • Auto & Transportation

      • All Automotive & Transportation
      • Aerospace, Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads and Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking and Road Transportation
      • Auto & Transportation Overview

      • View All Auto & Transportation

      • Business Technology

      • All Business Technology
      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • Business Technology Overview

      • View All Business Technology

      • Entertain­ment & Media

      • All Entertain­ment & Media
      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • Entertain­ment & Media Overview

      • View All Entertain­ment & Media

      • Financial Services & Investing

      • All Financial Services & Investing
      • Accounting News & Issues
      • Acquisitions, Mergers and Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalization
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • Financial Services & Investing Overview

      • View All Financial Services & Investing

      • General Business

      • All General Business
      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls and Research
      • Trade Show News
      • General Business Overview

      • View All General Business

  • Science & Tech
      • Consumer Technology

      • All Consumer Technology
      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • Consumer Technology Overview

      • View All Consumer Technology

      • Energy & Natural Resources

      • All Energy
      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil and Gas Discoveries
      • Utilities
      • Water Utilities
      • Energy & Natural Resources Overview

      • View All Energy & Natural Resources

      • Environ­ment

      • All Environ­ment
      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • Environ­ment Overview

      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • All Heavy Industry & Manufacturing
      • Aerospace & Defense
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation and Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking and Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • Heavy Industry & Manufacturing Overview

      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • All Telecomm­unications
      • Carriers and Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • Telecomm­unications Overview

      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • All Consumer Products & Retail
      • Animals & Pets
      • Beers, Wines and Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics and Personal Care
      • Fashion
      • Food & Beverages
      • Furniture and Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewelry
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • Consumer Products & Retail Overview

      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • All Entertain­ment & Media
      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • Entertain­ment & Media Overview

      • View All Entertain­ment & Media

      • Health

      • All Health
      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • Health Overview

      • View All Health

      • Sports

      • All Sports
      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • Sports Overview

      • View All Sports

      • Travel

      • All Travel
      • Amusement Parks and Tourist Attractions
      • Gambling & Casinos
      • Hotels and Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • Travel Overview

      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • All Policy & Public Interest
      • Advocacy Group Opinion
      • Animal Welfare
      • Canadian Federal Government
      • Canadian Municipal Government
      • Canadian Provincial Government
      • Corporate Social Responsibility
      • Domestic Policy
      • Economic News, Trends, Analysis
      • Education
      • Environmental
      • European Government
      • FDA Approval
      • Federal and State Legislation
      • Federal Executive Branch & Agency
      • Foreign Policy & International Affairs
      • Homeland Security
      • Labor & Union
      • Legal Issues
      • Natural Disasters
      • Not For Profit
      • Patent Law
      • Public Safety
      • Trade Policy
      • Policy & Public Interest Overview

      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • All People & Culture
      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • People & Culture Overview

      • View All People & Culture

  • Advanced Search
  • Overview
  • Cision Communications Cloud®
  • Monitoring
  • Distribution
  • Multimedia
  • Guaranteed Paid Placement
  • Analytics
  • IR
  • Become a Client
  • Request a Demo
  • Editorial Bureaus
  • Partnerships
  • General Enquiries
  • Media
  • Worldwide Offices
  • Cision Canada
  • Send a Release
  • FR
    • Phone

    • 877-269-7890 from 8 AM - 10 PM ET

    • ALL CONTACT INFO
    • Contact Cision

      877-269-7890
      from 8 AM - 10 PM ET

  • Send a Release
  • Sign Up
  • Resources
  • Blog
  • Journalists
  • Webcasts
  • GDPR
  • News in Focus
    • Browse All News
    • Multimedia Gallery
    • Trending Topics
  • Business
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
    • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Send a Release
  • Sign Up
  • Resources
  • Blog
  • Journalists
  • Webcasts
  • GDPR
  • Overview
  • Cision Communications Cloud®
  • Monitoring
  • Distribution
  • Multimedia
  • Guaranteed Paid Placement
  • Analytics
  • IR
  • Send a Release
  • Sign Up
  • Resources
  • Blog
  • Journalists
  • Webcasts
  • GDPR
  • Become a Client
  • Request a Demo
  • Editorial Bureaus
  • Partnerships
  • General Enquiries
  • Media
  • Worldwide Offices
  • Send a Release
  • Sign Up
  • Resources
  • Blog
  • Journalists
  • Webcasts
  • GDPR

More Proof Lung Cancer is Not One Disease: New Investigational Treatment, Nintedanib* Plus Chemotherapy, Extends Life of Lung Cancer Patients With Adenocarcinoma


News provided by

Boehringer Ingelheim (Canada) Ltd.

03 Jun, 2013, 07:30 ET

Share this article

Share this article


New trial results presented at American Society of Clinical Oncology (ASCO) 2013 represent first advance in almost a decade in overall survival for patients where initial chemotherapy has failed

BURLINGTON, ON, June 3, 2013 /CNW/ - New research on Canada's number one cancer killer1 is further proof that patients need personalized treatments targeted to their specific type of lung cancer for better outcomes.  Boehringer Ingelheim (Canada) Ltd. today announced highly anticipated results from the Phase III LUME-Lung 1 study in patients with advanced non-small cell lung cancer (NSCLC).  The primary endpoint was progression-free survival (PFS) and the results showed patients treated with nintedanib plus chemotherapy (docetaxel) lived for a median of 3.4 months before their tumour started to grow again, versus 2.7 months with docetaxel alone (HR 0.79; p=0.0019).2 The study also examined the secondary endpoint of overall survival (OS),2 and in the process uncovered a specific group of patients who respond particularly well to the combination therapy.

The trial examined a sub-group of patients with adenocarcinoma histology - the most common type of NSCLC.3 It showed that patients with adenocarcinoma whose disease progressed during first-line therapy or shortly after lived for an additional 2.3 months in the nintedanib combination treatment arm versus with docetaxel alone.  Specifically, the median overall survival (the gold standard measure of success in lung cancer treatment) was 12.6 months in the nintedanib combination treatment arm versus 10.3 months with docetaxel alone (HR 0.75; p=0.0073).2  

"These study results are significant because they show us that nintedanib may become an interesting option for some subsets of patients with lung cancer," says Dr. Normand Blais, medical oncologist at the Centre Hospitalier de l'Université de Montréal (CHUM) in Montreal.  "This is big news for the lung cancer community because patients progressing after a first-line treatment need more efficient treatments to control their cancers. As an oncologist I want to offer my patients the best treatment options available and it is encouraging to see new options in development that may help us devise more efficacious and individualized treatment approaches."

"Personalized medicine has changed the face of lung cancer treatment and we now know lung cancer is not just one disease, so we need to consider this when conducting new research," said Dr. Mathias Knecht M.D., Vice President Medical and Regulatory Affairs, Boehringer Ingelheim (Canada) Ltd.  "For this reason Boehringer Ingelheim is investigating two drugs for NSCLC - afatinib* and nintedanib* - both which address the unmet needs of two distinct lung cancer patient populations. These most recent nintedanib results represent some of the latest advancements from Boehringer Ingelheim's robust oncology pipeline."

About the LUME-Lung 1 Trial
LUME-Lung 1 (Clinical Trial Identifier: NCT00805194)is a randomized, open-label, double-blind Phase III study evaluating nintedanib plus docetaxel in patients with locally advanced or metastatic (stage IIIb/IV or recurring) non-small cell lung cancer (NSCLC) after prior first-line therapy, compared to docetaxel plus placebo. The study included 1,314 patients in Europe, Asia and South Africa,4 randomized to receive nintedanib 200 mg BID plus docetaxel 75mg/m2 once a day, for three weeks (n=655) or docetaxel plus placebo (n=659).2

The primary endpoint was PFS; results showed patients treated with nintedanib plus docetaxel lived for a median of 3.4 months before their tumour started to grow again, versus 2.7 months with docetaxel alone (HR 0.79; p=0.0019).2

The secondary endpoint of OS was evaluated in the full study population, as well as in the sub-group of patients with adenocarcinoma histology - the most common type of NSCLC.3 Overall survival was evaluated in the following sequence: patients with adenocarcinoma histology whose disease progressed during first-line therapy or shortly after (less than 9 months since the start of first-line therapy); all patients with adenocarcinoma histology; and, all study participants (full study population). In the group of patients with adenocarcinoma histology whose disease progressed during first-line therapy or shortly after, the median OS was 10.9 months in the nintedanib combination treatment arm versus 7.9 months with docetaxel alone (HR: 0.75; p=0.0073).2 In all patients with adenocarcinoma histology, the median OS was 12.6 months in the nintedanib combination arm versus 10.3 months with docetaxel alone (HR: 0.83; p=0.0359).2 In the full study population, the median OS was 10.1 months in the nintedanib combination arm versus 9.1 months with docetaxel alone (HR 0.94; p=0.272).2

The most common adverse events (AEs) in LUME-Lung 1 were gastrointestinal side effects and liver enzyme elevations which were manageable by supportive treatment or dose reduction (adverse events placebo vs. nintedanib: nausea 18 per cent vs. 24 per cent, vomiting 9 per cent vs. 17 per cent, diarrhoea 22 per cent vs. 42 per cent and liver enzymes 8 per cent vs. 29 per cent).2

LUME-Lung 1 is part of the wider Boehringer Ingelheim LUME-Lung Phase III program for nintedanib investigating the safety and efficacy of nintedanib in NSCLC patients after first-line chemotherapy treatment.

About Non-Small Cell Lung Cancer (NSCLC)
NSCLC is the most common form of lung cancer, accounting for about 85 per cent of all diagnoses.5 Adenocarcinoma is the most common type of NSCLC, accounting for 40 per cent of all NSCLC diagnoses.3

About Lung Cancer in Canada
According to the Canadian Cancer Society, in 2012 an estimated 25,600 Canadians were diagnosed with lung cancer,6 and 20,100 died from it.7 In fact, more people were estimated to die from lung cancer in 2012 than from colorectal, breast and prostate cancer combined.8 As the leading cause of cancer death in both men and women in Canada,9 its estimated an average of 55 Canadians die from lung cancer every day.1

Lung cancer is also grossly under researched and under-funded. It only gets 7 per cent of cancer-specific research funding and 0.1 per cent of cancer donations, despite the fact that it causes 27 per cent of cancer-related deaths.11

Notes to Editors:

About Nintedanib
Nintedanib (BIBF 1120) is an investigational orally-administered triple angiokinase inhibitor that targets three of the receptor tyrosine kinases shown to aid in the regulation of angiogenesis: fibroblast growth factor (FGF) receptor, platelet-derived growth factor (PDGF) receptor, and vascular endothelial growth factor (VEGF) receptor.

Nintedanib is being evaluated in various solid tumours - including advanced non-small cell lung cancer (NSCLC), ovarian cancer, liver cancer (hepatic cell carcinoma), kidney cancer (renal cell carcinoma) and colorectal cancer. The advanced NSCLC and ovarian cancer clinical trials are in Phase III development. Nintedanib is also being investigated in Phase III trials for the treatment of Idiopathic Pulmonary Fibrosis (IPF), a progressive and severely debilitating lung disease.  Nintedanib is not approved by Health Canada; its safety and efficacy have not been established.

About Boehringer Ingelheim in Oncology
Building on scientific expertise and excellence in the fields of pulmonary and cardiovascular medicine, metabolic disease, neurology, virology and immunology, Boehringer Ingelheim has embarked on a major research program to discover and develop innovative cancer treatments.  Working in close collaboration with the international scientific community and a number of the world's leading cancer centers, Boehringer Ingelheim's commitment to oncology is underpinned by using advances in science to develop a range of targeted therapies for various solid tumours and hematological cancers. The current focus of late-stage research includes compounds in three areas: signal transduction inhibition, angiogenesis inhibition and cell-cycle kinase inhibition. The company is also evaluating a robust and growing pipeline of early-stage oncology compounds in areas including growth/survival signaling, immunotherapy and epigenetics.

About Boehringer Ingelheim (Canada) Ltd.
The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 140 affiliates and more than 46,000 employees. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel medications of high therapeutic value for human and veterinary medicine.

As a central element of its culture, Boehringer Ingelheim pledges to act socially responsible. Involvement in social projects, caring for employees and their families, and providing equal opportunities for all employees form the foundation of the global operations. Mutual cooperation and respect, as well as environmental protection and sustainability are intrinsic factors in all of Boehringer Ingelheim's endeavors.

In 2012, Boehringer Ingelheim achieved net sales of about 14.7 billion euro. R&D expenditure in its Prescription Medicines business corresponds to 22.5% of its net sales.

The Canadian headquarters of Boehringer Ingelheim was established in 1972 in Montreal, Quebec and is now located in Burlington, Ontario.  Boehringer Ingelheim employs more than 550 people across Canada.  For more information please visit www.boehringer-ingelheim.ca.

References 


1 Canadian Cancer Society's Steering Committee on Cancer Statistics. Canadian Cancer Statistics 2012. Toronto, ON: Canadian Cancer Society; 2012, Page 9.
2   Reck M. Nintedanib (BIBF 1120) + docetaxel in NSCLC patients progressing after first-line chemotherapy: LUME Lung 1, a randomized, double blind phase 3 trial. Oral Presentation (Abstract #LBA8011) at American Society of Clinical Oncology, Chicago, June 2, 2013.
3   American Cancer Society. Lung Cancer (Non-Small Cell). Available at:
http://www.cancer.org/acs/groups/cid/documents/webcontent/003115-pdf.pdf. Last Accessed May 7, 2013.
4   ClinicalTrials.gov. LUME-Lung 1: BIBF 1120 Plus Docetaxel as Compared to Placebo Plus Docetaxel in 2nd Line Non Small Cell Lung Cancer. Available at: http://clinicaltrials.gov/ct2/show/study/NCT00805194?show_locs=Y#locn. Last accessed May 21, 2013.
5  American Cancer Society.  Cancer Facts and Figures: 2012.  Available at: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf.  Last accessed April 27, 2012.
6 Canadian Cancer Society's Steering Committee: Canadian Cancer Statistics 2012. Toronto, ON: Canadian Cancer Society; 2012, Page 8.
7 Canadian Cancer Society's Steering Committee: Canadian Cancer Statistics 2012. Toronto, ON: Canadian Cancer Society; 2012, Page 9.
8 Ibid
9 Canadian Cancer Society's Steering Committee: Canadian Cancer Statistics 2012. Toronto, ON: Canadian Cancer Society; 2012, Page 7.
10 Canadian Cancer Society's Steering Committee: Canadian Cancer Statistics 2012. Toronto, ON: Canadian Cancer Society; 2012, Page 9.
11 Charity Intelligence Canada: Cancer in Canada. April 2011. Page 39.

*Afatinib and Nintedanib are investigational compounds. Their safety and efficacy have not yet been fully established and they are not currently authorized for sale in Canada.

Video with caption: "Video: Dr. Vera Hirsh, Associate Professor, McGill University, Department of Medical Oncology, Royal Victoria Hospital, Montreal, Canada talks about a new era of personalized medicine in lung cancer.". Video available at: http://stream1.newswire.ca/cgi-bin/playback.cgi?file=20130603_C4194_VIDEO_EN_27364.mp4&posterurl=http://photos.newswire.ca/images/20130603_C4194_PHOTO_EN_27364.jpg&clientName=Boehringer%20Ingelheim%20%28Canada%29%20Ltd%2E&caption=Video%3A%20Dr%2E%20Vera%20Hirsh%2C%20Associate%20Professor%2C%20McGill%20University%2C%20Department%20of%20Medical%20Oncology%2C%20Royal%20Victoria%20Hospital%2C%20Montreal%2C%20Canada%20talks%20about%20a%20new%20era%20of%20personalized%20medicine%20in%20lung%20cancer%2E&title=BOEHRINGER%20INGELHEIM%20%28CANADA%29%20LTD%2E%20%2D%20More%20Proof%20Lung%20Cancer%20is%20Not%20One%20Disease%3A%20New%20Investigational%20Treatment%2C%20Nintedanib%2A%20Plus%20Chemotherapy%2C%20Extends%20Life%20of%20Lung%20Cancer%20Patients%20With%20Adenocarcinoma&headline=More%20Proof%20Lung%20Cancer%20is%20Not%20One%20Disease%3A%20New%20Investigational%20Treatment%2C%20Nintedanib%2A%20Plus%20Chemotherapy%2C%20Extends%20Life%20of%20Lung%20Cancer%20Patients%20With%20Adenocarcinoma

SOURCE: Boehringer Ingelheim (Canada) Ltd.

For further information:

Morgan Cates
Environics Communications
416-969-2789
[email protected]

Modal title

Organization Profile

Boehringer Ingelheim (Canada) Ltd.

    Also from this source

  • Health Canada approves first treatment option for generalized pustular psoriasis flares in adults

Contact Cision

  • 877-269-7890
    from 8 AM - 10 PM ET

  • Become a Client
  • Request a Demo
  • Editorial Bureaus
  • Partnerships
  • General Enquiries
  • Media
  • Worldwide Offices

Products

  • Cision Communications Cloud®
  • Media Monitoring
  • Content Distribution
  • Multimedia Distribution
  • Measurement & Analytics
  • Investor Relations

About

  • About Cision Canada
  • About Cision
  • Media Partners
  • Careers
  • Accessibility Statement

My Services

  • All News Releases
  • Online Member Centre
  • Next Gen Communications Cloud
  • Cision Communications Cloud®
  • my CNW

Contact Cision

Products

About

My Services
  • All News Releases
  • Online Member Centre
  • Next Gen Communications Cloud
  • Cision Communications Cloud
  • my CNW
877-269-7890
from 8 AM - 10 PM ET
  • Terms of Use
  • Information Security Policy
  • Site Map
  • Cookie Settings
  • Accessibility Statement
Copyright © 2023 CNW Group Ltd. All Rights Reserved. A Cision company.