Unique genetic pathology centre set to change the way we treat cancer
GPEC receives an unrestricted grant of
GPEC is responsible for a number of important cancer related discoveries, including a genetic change in a tumour previously thought to be an aggressive form of arthritis, that ovarian cancer is at least five distinct diseases and new methods for diagnosis of breast cancer subtypes in hospital pathology laboratories. The value and the impact of these and other accomplishments has allowed this relatively small but productive centre - which has published more than 200 peer-reviewed articles in the last five years - to establish itself as a worldwide leader in its field.
"The results of our research have changed the way cancers are either diagnosed or managed," said Blake Gilks, one of the three lead investigators at GPEC. "However, promising discoveries are dependent on sustained sources of funding from organizations like sanofi-aventis, who has been behind us for seven years now. This additional funding is the lift we need to help us continue to move away from a one-size-fits-all to a personalized approach to cancer treatment."
The centre now wants to focus on building on the important work it has already accomplished in the realm of breast cancer. GPEC played a leading role in defining the molecular subtypes of breast cancer in 2004 - their first paper on the topic became the fourth most cited paper ever in the Clinical Cancer Research journal. Today, they are at the cutting edge in determining the response of different breast cancer subtypes to different treatments. Subtype specific treatments for breast cancer, which are tailored to the molecular abnormalities in each subtype, are saving lives.
Another GPEC project concerns a little understood and difficult to treat tumour of the ovary. After having helped decode ovarian cancers with state-of-the-art genome sequencing technologies, in collaboration with the BC Cancer Agency's Genome Sciences Centre, they identified a recurring mutation in granulosa-cell tumours of the ovary, and GPEC is now working on new diagnostics and treatments for this cancer.
With the work already accomplished and the many projects ahead, the centre is well-positioned to play a critical role in translating fundamental research into clinic practice.
"Sanofi-aventis believes that research into personalized medicine is a great way to deliver value to the Canadian healthcare system," said Hugh O'Neill, President and CEO of sanofi-aventis
About the Genetic Pathology Evaluation Center (GPEC)
The Genetic Pathology Evaluation Centre (GPEC) is a laboratory specialized in the assessment of novel cancer biomarkers by means of tissue microarray technology. The Centre was founded in 2001 and is a collaborative research venture of the Prostate Research Centre at the VGH, the
For more information about:
BC Cancer Agency, please visit: http://www.bccancer.bc.ca Vancouver Coastal Health Research Institute (VCHRI), please visit: http://www.vchri.ca sanofi-aventis, please visit: http://www.sanofi-aventis.ca
For further information: or to coordinate interviews with either GPEC, the BC Cancer Agency (BCCA), the Vancouver Coastal Health Research Institute (VCHRI) or sanofi-aventis: Lisa Carver, Vancouver Coastal Health Research Institute, (604) 875-4111, ext. 61777, Cell: (604) 319-7533, [email protected]; Claire Alter, NATIONAL Public Relations, (604) 691-7393, Cell: (604) 812-5464, [email protected]
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