TORONTO, Nov. 18, 2013 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI) (TSX: TTH) announced ELND005 (scyllo-inositol) was featured in an oral and two poster presentations at the recently completed 6th Annual Clinical Trials in Alzheimer's Disease meeting that occurred November 13-16 in San Diego, CA. In addition, the conference included symposia that examined "Agitation and Aggression in AD: a new target for drug development" and "AD and Down Syndrome."
The ELND005 presentations were entitled:
|"Effects of ELND005 (Scyllo-inositol) long term treatment on Amyloid related imaging abnormalities (ARIA) in Phase 2 AD studies"|
|"Dose selection for ELND005 (Scyllo-inositol) in neuropsychiatric clinical trials: Use of Modeling and simulations (M&S) of population pharmacokinetic model to estimate target drug exposures"|
|"Effects of ELND005 (Scyllo-inositol) and Clozapine on social withdrawal behaviors: Differential Profiles in a PCP animal model"|
ELND005 is an orally bioavailable small molecule that is being investigated by Transition's licensing partner, Elan, for multiple neuropsychiatric indications on the basis of its proposed dual mechanism of action, which includes β-amyloid anti-aggregation and regulation of brain myo-inositol levels. An extensive clinical program of Phase 1 and Phase 2 studies have been completed with ELND005 to support clinical development, including the published Phase 2 study ELND005-AD201 in AD. ELND005 is also being studied as a potential treatment of agitation and aggression in Alzheimer's disease (Study ELND005-AG201), as a maintenance therapy of Bipolar Disorder Type I (Study ELND005-BPD201) and as a therapy for those with Down syndrome (Study ELND005-DS-201).
Transition is a biopharmaceutical company, developing novel therapeutics for disease indications with large markets. The Company's lead CNS drug candidate is ELND005 for the treatment of Alzheimer's disease and bipolar disorder. Transition's lead metabolic drug candidate is TT-401 for the treatment of type 2 diabetes and accompanying obesity. The Company's shares are listed on the NASDAQ under the symbol "TTHI" and the Toronto Stock Exchange under the symbol "TTH". For additional information about the Company, please visit www.transitiontherapeutics.com.
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SOURCE: Transition Therapeutics Inc.
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