Novel target is fifth in a series of potential targets on prion-like strains of misfolded Amyloid beta, implicated in the development and progression of AD
TORONTO, June 21, 2016 /CNW/ - ProMIS Neurosciences ("ProMIS" or the "Company"), a company focused on the discovery and development of precision treatments for neurodegenerative diseases, today announced that it has identified and submitted a provisional patent application for a fifth novel therapeutic target on prion-like strains of misfolded Amyloid beta (Ab), implicated in the development and progression of AD.
"Multiple therapeutic candidates against all five of the novel targets we have identified demonstrated, during the screening phase, selective binding to misfolded strains of Amyloid beta, with no measurable off-target binding," said Dr. Elliot Goldstein, ProMIS CEO. "These candidates are currently being evaluated for their binding profiles in cadaveric brain tissue from patients with a confirmed diagnosis of Alzheimer's. We are looking forward to the results of these validation studies, which will enable the selection of therapeutic products for drug development."
ProMIS Neurosciences submitted a provisional patent application for its fifth novel Alzheimer's disease target to the United States Patent Office on June 20, 2016, pursuant to its expanded license agreement with the University of British Columbia (announced on October 8, 2015).
The Company applied its unique, proprietary discovery platforms, ProMISTM and Collective Coordinates, to identify this fifth, novel target (epitope) on prion-like strains of misfolded Ab.
About ProMIS Neurosciences, Inc.
The mission of ProMIS Neurosciences is to discover and develop precision medicine therapeutics for effective treatment of neurodegenerative diseases, in particular Alzheimer's disease and ALS.
ProMIS Neurosciences' proprietary target discovery engine is based on the use of two, complementary techniques. The Company applies its thermodynamic, computational discovery platforms—ProMIS™ and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique "precision medicine" approach, ProMIS Neurosciences is developing novel antibody therapeutics and specific companion diagnostics for Alzheimer's disease and ALS. The company has also developed two proprietary technologies to specifically identify very low levels of misfolded proteins in a biological sample. In addition, ProMIS Neurosciences owns a portfolio of therapeutic and diagnostic patents relating to misfolded SOD1 in ALS, and currently has three preclinical monoclonal antibody therapeutics against this target.
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SOURCE ProMIS Neurosciences Inc.
For further information: NATIONAL Equicom: Michael Moore: [email protected], Abby Garfunkel: [email protected]; or contact, Dr. Elliot Goldstein, President and Chief Executive Officer, ProMIS Neurosciences Inc., Tel. 415 341-5783, [email protected]