Long-term Aspirin use Reduces the Incidence of Digestive Cancers by up to 47%, Study Presented at UEG Week Reveals

The long-term use of aspirin has been shown to significantly reduce the incidence of digestive cancers, new research presented today at the 25^th UEG Week have found^[1].

BARCELONA, Spain, Oct. 30, 2017 /CNW/ - In a study involving over 600,000 people, researchers compared patients who were prescribed aspirin over a long period (for at least six months, average duration of aspirin prescribed was 7.7 years) with non-aspirin users and assessed the incidences of a number of cancers. Those prescribed with aspirin showed a 47% reduction in liver and oesophageal cancer incidence, a 38% reduction in gastric cancer incidence, a 34% reduction in pancreatic cancer incidence and a 24% reduction in colorectal cancer incidence.

Digestive cancers account for almost a quarter of cancer cases in Europe^[2]. Colorectal, gastric and pancreatic cancer are within the top five cancer killers throughout the continent, with digestive cancers representing 30.1% of cancer deaths.

Aspirin is used across the globe to treat a number of health conditions, ranging from short-term pain relief to long-term prescriptions. Whilst the use of aspirin is subject to continued debate within the medical community, a recent study found that patients who stopped taking aspirin were 37% more likely to have an adverse cardiovascular event, such as a heart attack or stroke, than those who continued with their prescription^[3].

Cancer Site	Reduction in incidence of cancer by aspirin user
	(compared with non-user)
Liver	47%
Oesophageal	47%
Gastric	38%
Pancreatic	34%
Colorectal	24%
Table 1 - Reduction in incidence of digestive cancer

The effect of long-term use of aspirin on cancer incidence was also examined for cancers outside of the digestive system. Here, a significant reduction was shown for some (leukaemia, lung and prostate) but not all (breast, bladder, kidney and multiple myeloma) cancers.

Lead researcher, Professor Kelvin Tsoi from the Chinese University of Hong Kong, presented the study today at the 25^th UEG Week in Barcelona. "The findings demonstrate that the long-term use of aspirin can reduce the risk of developing many major cancers," commented Professor Tsoi. "What should be noted is the significance of the results for cancers within the digestive tract, where the reductions in cancer incidence were all very substantial, especially for liver and oesophageal cancer."

References:

1. Tsoi, K. et al. Long-term use of aspirin is more effective to reduce the incidences of gastrointestinal cancers than non-gastrointestinal cancers: A 10-year population based study in Hong Kong. Presented at UEG Week Barcelona 2017.

2. GLOBOCAN, IARC (2012). Section of Cancer Surveillance.

3. Stopping aspirin treatment raises cardiovascular risk by over a third (2017). Available at: https://www.medicalnewstoday.com/articles/319541.php

SOURCE United European Gastroenterology (UEG)