STOCKHOLM, Feb. 22, 2012 /CNW/ - A double-blind, placebo-controlled
study of 494 children showed that supplementation of Lactobacillus reuteri Protectis significantly reduced episodes of diarrhoea. Lactobacillus reuteri Protectis was particularly effective in children with lower nutritional
status. Another probiotic strain, which was also tested, was without
The six month long double-blind, placebo-controlled study was performed
in Indonesia and included 494 healthy children aged one to six years.
The children were randomly assigned to receive low-lactose milk with or
without Lactobacillus casei 431 or Lactobacillus reuteri DSM17938.
Primary outcome was number and duration of acute diarrhoeal episodes.
Diarrhoea was measured both according to the World Health
Organisation's definition of diarrhoea, ≥3 loose/liquid stools in 24
hours, and as incidence of all diarrhoea, ≥2 loose/liquid stools in 24
hours. Secondary outcome was number and duration of acute respiratory
Significant results only with Lactobacillus reuteri Protectis
The results showed that the incidence of all diarrhoea episodes was
significantly reduced by 32 per cent in the group supplemented by Lactobacillus reuteri Protectis compared to placebo. In children with lower nutritional status (below
median height and weight for the age group) Lactobacillus reuteri Protectis had significant effect on both WHO defined and all episodes of
None of the other interventions showed any significant effects on either
WHO defined or all episodes of diarrhoea and none of the interventions
affected incidence or duration of acute respiratory infections. An
additional finding was significantly reduced antibiotic use in the Lactobacillus reuteri Protectis supplemented children compared to those given placebo.
The study was conducted independently from BioGaia and the results were announced in a press release by NIZO food research
on 21 February 2012: http://www.nizo.com/news/latest-news/56/bovee/
The study will be published in Journal of Pediatrics. Doctor Rina
Agustina will also present the results at the International Symposium
of Probiotics and Prebiotics in Pediatrics (IS3P) on 24 February 2012.
"These new and very positive results with Lactobacillus reuteri Protectis confirm earlier studies with this probiotic strain in children with
acute diarrhoea. As the other probiotic tested in the study did not
show any positive effects, this strengthens the importance of using the
right strain when choosing a probiotic," says Peter Rothschild,
President at BioGaia.
SOURCE BioGaia AB
For further information:
Peter Rothschild, President, telephone: +46-8-555-293-00
Eamonn Connolly, Senior Vice President Research, telephone: +46-8-555-293-00
About the company: http://www.biogaia.com