Study Presented at ASCO Shows Encouraging One-Year and Overall Survival Results for Phase I/II Trial of OGX-011 in Non-Small Cell Lung Cancer

    VANCOUVER, BC and CARLSBAD, CA, June 3 /CNW/ - OncoGenex Technologies
Inc. and Isis Pharmaceuticals, Inc. (Nasdaq:   ISIS) today announced encouraging
preliminary data from a Phase I/II clinical trial of OGX-011 in first-line
combination therapy for advanced non-small cell lung cancer (NSCLC). Data were
presented by Janessa Laskin, M.D., a medical oncologist at the BC Cancer
Agency, at the Annual Meeting of the American Society of Clinical Oncology
(ASCO) in Chicago.
    In this single-arm, open-label study, 81 patients with Stage IIIB (18
percent) or Stage IV (82 percent) NSCLC were treated with OGX-011, 78 of whom
were treated at the Phase II dose of 640 mg per week by intravenous infusion,
in combination with a standard first-line NSCLC chemotherapy regimen that
included gemcitabine and either cisplatin or carboplatin.

    Survival Results:
    -   At the time of analysis, the estimated median overall survival was 14
        months, with follow up ongoing. For comparison, published studies
        using a platinum-based regimen plus gemcitabine as first-line
        chemotherapy for advanced NSCLC report median survivals of 8 to 11
    -   The one-year survival rate for the 46 of 81 patients who had been
        followed for at least one year was 54 percent; published data
        document one-year survival rates in the 33 to 43 percent range.
    -   The 18-month survival rate for the 22 patients who had been followed
        for at least 18 months was 36 percent, with follow up ongoing.

    Objective Response Results:
    -   Among the 81 patients in the study, 26 percent experienced objective
        tumor responses, 40 percent experienced disease stabilization, 28
        percent experienced disease progression, and response was not
        assessable in 6 percent.

    "The one-year survival rate of 54 percent and the estimated median
overall survival of 14 months compare favorably with previously reported
studies and support further evaluation of the potential for OGX-011 as an
additional combination therapy for advanced NSCLC," said Dr. Laskin.
    "The progression and survival data are very encouraging. As we've
previously communicated, we plan to convene an expert NSCLC advisory panel to
discuss these data, and we will consider both the data and the panel's
recommendations in our planning for upcoming pivotal studies to confirm the
efficacy of OGX-011," said Scott Cormack, president and CEO of OncoGenex.
    The investigators concluded that the treatment with OGX-011 was generally
well tolerated in combination with this chemotherapy regimen. The most common
grade 3 or 4 non-hematologic toxicities were hyponatremia (23 percent),
fatigue (15 percent), infection (10 percent), nausea (10 percent) and vomiting
(10 percent). The most common grade 3 or 4 hematologic toxicities were
neutropenia (47 percent in combination with cisplatin and 60 percent in
combination with carboplatin), lymphopenia (35 percent in combination with
cisplatin and 20 percent in combination with carboplatin), thrombocytopenia
(25 percent in combination with cisplatin and 45 percent in combination with
carboplatin) and anemia (9 percent in combination with cisplatin and 20
percent in combination with carboplatin). In general these toxicities were
consistent with the adverse event profile for gemcitabine in combination with
a platinum-based regimen in this population. The addition of OGX-011 to
gemcitabine/platinum-containing regimen may have increased the frequency of
grade 3 or 4 neutropenia and thrombocytopenia compared with published data,
but with the addition of OGX-011 there was no increase above the expected
frequency of treatment with growth factors and platelet transfusions or the
expected incidence of infection and febrile neutropenia.
    OGX-011 is designed to specifically inhibit the production of the
cell-survival protein, clusterin. Clusterin production is associated with
treatment resistance in many cancers and in response to various cancer
treatments, including hormone ablation therapy, chemotherapy and radiation
therapy. Preclinical studies have shown that inhibition of clusterin can
disable the tumor cells' adaptive defences, render the tumor cells susceptible
to attack with a variety of cancer therapies, including chemotherapy, and
facilitate tumor-cell death. OncoGenex and Isis are collaborating on
development of OGX-011.
    The study was sponsored by OncoGenex Technologies Inc.

    About OncoGenex

    OncoGenex is committed to the development and commercialization of new
cancer therapies that address treatment resistance in cancer patients.
OncoGenex currently has three product candidates in development: OGX-011,
OGX-427 and OGX-225. These product candidates are designed to selectively
inhibit the production of proteins that are associated with treatment
resistance and that are over-produced in response to a variety of cancer
treatments. OncoGenex' aim in targeting these particular proteins is to
disable the tumor cells' adaptive defenses, render the tumor cells susceptible
to attack with a variety of cancer therapies including chemotherapy, and
facilitate tumor cell death. More information on OncoGenex and the company's
pipeline is available at

    About Isis Pharmaceuticals, Inc.

    Isis is exploiting its expertise in RNA to discover and develop novel
drugs for its product pipeline and for its partners. The Company has
successfully commercialized the world's first antisense drug and has 17 drugs
in development. Isis' drug development programs are focused on treating
cardiovascular and metabolic diseases. Isis' partners are developing drugs for
cancer, and inflammatory and other diseases. Ibis Biosciences, Inc., Isis'
wholly owned subsidiary, is developing and commercializing the Ibis T5000
Biosensor System, a revolutionary system to identify infectious organisms. As
an innovator in RNA-based drug discovery and development, Isis is the owner or
exclusive licensee of over 1,500 issued patents worldwide. Additional
information about Isis is available at

    Isis Pharmaceuticals, Inc. Forward-Looking Statement

    This press release includes forward-looking statements regarding the
development, activity, therapeutic potential and safety of OGX-011 in treating
cancer. Any statement describing Isis' goals, expectations, financial or other
projections, intentions or beliefs is a forward-looking statement and should
be considered an at-risk statement, including those statements that are
described as Isis' goals. Such statements are subject to certain risks and
uncertainties, particularly those inherent in the process of discovering,
developing and commercializing drugs that are safe and effective for use as
human therapeutics, and in the endeavor of building a business around such
products. Isis' forward-looking statements also involve assumptions that, if
they never materialize or prove correct, could cause its results to differ
materially from those expressed or implied by such forward-looking statements.
Although Isis' forward-looking statements reflect the good faith judgment of
its management, these statements are based only on facts and factors currently
known by Isis. As a result, you are cautioned not to rely on these
forward-looking statements. These and other risks concerning Isis' programs
are described in additional detail in Isis' annual report on Form 10-K for the
year ended December 31, 2006, and its quarterly report on Form 10-Q for the
quarter ended March 31, 2007, which are on file with the SEC. Copies of this
and other documents are available from the Company.

    Isis Pharmaceuticals, Ibis Biosciences and Ibis T5000 are registered
trademarks or trademarks of Isis Pharmaceuticals, Inc.

For further information:

For further information: OncoGenex Contact: Scott Cormack, President &
CEO, (604) 630-5400; OncoGenex Media Contact: Rachel Lipsitz, Porter Novelli
Life Sciences, (858) 449-9575; Isis Contact: Kate Corcoran, Vice President,
Corporate Development, (760) 603-2712

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