Safeguard Scientifics CEO Joins Keynote Roundtable at Red Herring Canada

    Peter J. Boni selected to participate on panel focusing on unique
investment business models

    WAYNE, PA., September 5 /CNW/ - Safeguard Scientifics, Inc. (NYSE:   SFE),
a holding company that builds value in growth-stage technology and life
sciences companies, today announced that President and CEO Peter J. Boni has
been selected to participate in Red Herring Canada's Keynote Roundtable on
Friday, September 7, 2007. The panel discussion, "The New Breed of Technology
Financiers," will be held from 9:45am-10:30am in the Hyatt Regency Hotel in
Montreal, Canada.

    "Innovation Illuminated" from Red Herring Canada is the first event
designed to highlight Canada's unique investment opportunities, and discuss
the most important topics and trends in the technology industry. The
conference is being held September 5, 2007 through September 7, 2007 in
Montreal, Canada.

    Boni brings more than 20 years of experience as the CEO at technology
companies in all stages of growth to the panel. At Safeguard, his goal is to
build on the company's legacy of identifying Technology and Life Sciences
companies with superior growth potential, and applying Safeguard's capital and
strategic, operational and management resources to enhance long-term value for
shareholders, partner companies and employees.

    "It's important for those looking for capital to recognize where their
backers are coming from," says Peter J. Boni, President and CEO of Safeguard
Scientifics. "Whether receiving financing from a holding company, a venture
capital firm or a private equity firm, each will have its own business model,
and it's important to work with a company whose management goals are similar
to your own. We hope that this panel discussion will highlight this, as well
as discuss the importance of business models for any technology company."

    About Safeguard

    Safeguard Scientifics, Inc. (NYSE:   SFE) builds value in growth-stage
technology and life sciences businesses. Safeguard provides growth capital as
well as a range of strategic, operational and management resources to our
partner companies. Safeguard participates in expansion financings, corporate
spin-outs, management buyouts, recapitalizations, industry consolidations and
early-stage financings.

    Except for the historical information and discussions contained herein,
statements contained in this release may constitute "forward-looking
statements" within the meaning of the Private Securities Litigation Reform Act
of 1995. Our forward-looking statements are subject to risks and
uncertainties. These forward-looking statements that could cause actual
results to differ materially, include, among others, managing rapidly changing
technologies, limited access to capital, competition, the ability to attract
and retain qualified employees, the ability to execute our strategy, the
uncertainty of the future performance of our companies, acquisitions and
dispositions of companies, the inability to manage growth, compliance with
government regulations and legal liabilities, additional financing
requirements, the effect of economic conditions in the business sectors in
which our companies operate, and other uncertainties described in the
Company's filings with the Securities and Exchange Commission. Many of these
factors are beyond our ability to predict or control. In addition, as a result
of these and other factors, our past financial performance should not be
relied on as an indication of future performance. The Company does not assume
any obligation to update any forward-looking statements or other information
contained in this press release.

For further information:

For further information: For Safeguard Scientifics Gregory FCA Kristy
Lash, 610-642-8253 Cell: 484-686-4775

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