Canadian independent medical study shows Bio-K+CL1285(R) can prevent antibiotic-associated diarrhea

    TORONTO, Nov. 28 /CNW/ - The Canadian Journal of Gastroenterology
November issue features a Canadian medical study(1) showing that a daily
intake of Bio-K+ CL1285 is a safe and effective means of preventing
antibiotic-associated diarrhea (AAD) in hospitalized patients, a growing
problem that has become an important public health concern. The probiotic used
in the study is available in Canada and the U.S., under the brand name
    The use of probiotics is gaining interest in the scientific community as
a potential measure to prevent AAD. In the randomized, double-blind,
placebo-controlled trial conducted from September 2003 to May 2004 at
Maisonneuve-Rosemont Hospital in Montreal, Quebec, hospitalized patients were
randomly assigned to receive either the Bio-K+ CL1285 formula or a placebo on
a daily basis for the entire duration of antibiotic treatment. Among 89
randomized patients, AAD occurred in 7 of 44 patients (15.9%) in the
Bio-K+Cl1285 group and in 16 of 45 patients (35.6%) in the placebo group
    "Antibiotic-Associated Diarrhea is a major concern for all patients
receiving antibiotics, and can lead to serious complications and extend the
hospitalization time," says Dr Pavel Hamet M.D., Ph.D., CSPQ, FRCP(C),
specialist at Hôtel-Dieu Hospital in Montreal, and chairman of the scientific
advisory committee. "This unique Canadian study is unequivocal scientific
proof of the beneficial health effects of Bio-K+CL1285(R) formula in
preventing AAD. While this Study focused on hospitalized patients, it is fair
to conclude that Bio-K+ would be equally effective in reducing the incidence
of AAD amongst non-hospitalized patients, as well," asserted Dr Hamet.
    Diarrhea is one of the most frequent side effects of antibiotic use. In
Canada approximately 21 million antibiotics prescriptions are written each
year, and in the US this number is over 161 million annually(3). Most
antibiotic treatments are prescribed in outpatient clinics.
    AAD occurs when antibiotics disrupt the natural balance of "good" and
"bad" bacteria in the intestinal tract, causing harmful bacteria to
proliferate far beyond their normal numbers. Often, the result is frequent
watery bowel movements. AAD can affect up to 35%(4) of patients receiving
antibiotic treatments.
    Most often, antibiotic-associated diarrhea is fairly mild and clears up
shortly after the patient stops taking the antibiotic. But sometimes the
patient may develop colitis, an inflammation of the large intestine, often in
a particularly serious form called "pseudomembranous colitis". Any form of
colitis can cause abdominal pain, fever and bloody diarrhea. Pseudomembranous
colitis can be life-threatening.
    There is increasing awareness that good bacteria must be present in high
numbers in the intestine to ensure proper function of the digestive system and
maintain the delicate balance of good digestive health.

    About Bio-K+CL1285(R)

    Bio-K+CL1285(R) contains a unique, powerful, and effective patented
formula of bacterial strains (Lb. Acidophilus, and Lb. Casei). It is available
in the form of 98g bottles of either fresh fermented milk or soy, containing a
minimum of 50 billion fresh, live and active bacteria at consumption, and as
enteric-coated capsules. Bio-K+CL1285(R) is currently used in 36 Canadian
hospitals and health centres, and is sold in the health specialized sections
of grocery stores, pharmacies and health stores across Canada and US.

    About Bio-K+ International Inc.

    Founded in 1994, Bio-K+ International Inc. is a family-owned Canadian
biotech company with its head offices located in Laval's scientific and
high-tech park. With more than 65 employees, Bio-K+ International Inc. is
dedicated to the manufacture, distribution and sale of Bio-K+CL1285(R)
products. For more information, please visit the web site

    Canadian Journal of Gastroenterology:

    (1)   Effect of fermented milk combining Lactobacillus acidophilus CL1285
          and Lactobacillus casei in the prevention of antibiotic-associated
          diarrhea: A randomized, double-blind, placebo-controlled trial,
          CANJ Gastroenterology, Vol 21, No 11, November 2007, 732:736.
    (2)   Product and placebo were provided by Bio-K+ International Inc,
          which also provided a research grant to cover the pharmacy
          administration fees.
    (3)   Canadian Bacterial Surveillance Network, February 2006, and CMA
          Foundation, 2006.
    (4)   McFarland LV. Epidemiology, risk factors and treatments for
          antibiotic-associated diarrhea. Dig Sis 1998;16(5): 292-307.

For further information:

For further information: or for interview opportunities, please contact
Porter Novelli: In Ontario and Eastern Canada: Katarina Markovinovic, Brenda
Paul-Ishikawa, (416) 422-7187, (416) 422-7173,,; In
Western Canada: Julie Coghlan, Kelly Cousins, (604) 602-6401, (604) 602-6405,,

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