Angiotech's corporate partner, Cook Medical, completes enrollment in first international trial of drug-eluting peripheral stent and files for CE Mark in Europe

    VANCOUVER, Sept. 10 /CNW/ - Angiotech Pharmaceuticals, Inc. ("Angiotech")
(NASDAQ:   ANPI, TSX: ANP), a global specialty pharmaceutical and medical device
company, today announced that its corporate partner, Cook Medical, has
completed enrollment in the first international clinical trial of a
drug-eluting stent designed to treat arterial blockages outside the coronary
arteries. The 420 patients enrolled in Cook's randomized trial of its Zilver
PTX Drug Eluting Peripheral Stent include peripheral arterial disease (PAD)
patients treated in Germany, the United States and Japan.
    "We would like to congratulate our partner Cook on completing enrollment
in this pioneering clinical program and for completing their CE Mark
submission in Europe," said Dr. Bill Hunter, President and CEO of Angiotech.
"The completion of this stage of the program demonstrates the continued
strength and breadth of our paclitaxel franchise, and brings us closer to
offering the same drug-eluting stent technology to patients with peripheral
artery disease that has benefited millions of coronary artery disease patients
to date."
    In many cases, PAD patients who have been treated with balloon
angioplasty and stenting experience restenosis, or renarrowing of the
arteries, over time and must undergo more invasive treatment such as bypass
surgery to restore blood flow to key arteries. The Zilver PTX trial
( was designed to determine whether the combination of
Cook's Zilver stent and the drug paclitaxel will keep peripheral arteries,
specifically the superficial femoral artery (SFA), open over time.
    Cook already has enrolled 780 patients in the European Union, Canada, and
Korea in a clinical registry to evaluate the safety of the Zilver PTX device.
Those data have been used for a submission in Europe for CE Mark approval to
market the device there, with additional regulatory submissions pending in
additional markets. In addition, Zilver PTX stent already has regulatory
approval for commercial use in New Zealand, Hong Kong and Singapore, where it
has been used to treat patients suffering from PAD.
    Cook licenses the rights to use paclitaxel with peripheral stents and
other non-coronary medical devices from Angiotech. Under the terms of its 1997
license agreement with Cook, Angiotech is entitled to receive royalty payments
upon the commercial sale of paclitaxel-eluting peripheral vascular stent
products, including the Zilver PTX.

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    About Angiotech

    Angiotech Pharmaceuticals, Inc. is a global specialty pharmaceutical and
medical device company with over 1,500 dedicated employees. Angiotech
discovers, develops and markets innovative treatment solutions for diseases or
complications associated with medical device implants, surgical interventions
and acute injury. To find out more about Angiotech (NASDAQ:   ANPI, TSX: ANP),
please visit our website at

For further information:

For further information: DeDe Sheel, Investor Relations and Corporate
Communications, Angiotech Pharmaceuticals, Inc., (415) 293-4412,

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