Angiotech's corporate partner, Boston Scientific, reports two-year SYNTAX data showing comparable safety outcomes for complex patients treated with Taxus(R) Express(R) stents and bypass surgery

    VANCOUVER and BARCELONA, Sept. 2 /CNW/ - Angiotech Pharmaceuticals, Inc.
(NASDAQ:   ANPI, TSX: ANP) today announced that its corporate partner, Boston
Scientific (NYSE:   BSX), has reported two-year data from its SYNTAX clinical
trial comparing percutaneous coronary intervention (PCI) using the Taxus(R)
Express(R) Paclitaxel-Eluting Coronary Stent System to coronary artery bypass
graft (CABG) surgery. The overall results demonstrated no statistically
significant difference between PCI and CABG in the composite safety endpoint
(all-cause death, stroke and myocardial infarction (MI)). Boston Scientific
made the announcement at the annual European Society of Cardiology (ESC)
Congress in Barcelona.
    "These results reinforce the one-year SYNTAX data and show impressive
outcomes for PCI in patients with complex coronary anatomy, the majority of
whom are normally treated with CABG surgery," said Keith D. Dawkins, M.D.,
Associate Chief Medical Officer of Boston Scientific. "Today's findings build
on our prior data and provide additional support for PCI as a viable treatment
option for many of these challenging patients."
    The patients in the SYNTAX trial - all of whom have left main and/or
three-vessel coronary disease - are a unique study group in the PCI field. In
the SYNTAX trial, mean stent use was 4.6 stents/patient, with one patient
having 14 stents implanted. By contrast, the average number of stents
implanted in a PCI patient in everyday practice is 1.5. In addition, the study
included 33 percent of patients with (greater than)100 mm stented length, 71
percent with bi/trifurcations, 27 percent with chronic total occlusions and 39
percent with left main disease.
    The results showed comparable safety profiles for the two treatment
groups at two years, with a combined rate of all-cause death, stroke and MI of
10.8 percent for PCI and 9.6 percent for CABG (p=0.44). The rate of stroke was
1.4 percent for PCI as compared to 2.8 percent for CABG (p=0.03), while MI was
5.9 percent for PCI and 3.3 percent for CABG (p=0.01). The rate of all-cause
death was 6.2 percent for PCI and 4.9 percent for CABG (p=0.24).
    Overall MACCE (Major Adverse Cardiovascular or Cerebrovascular Event
rate, including all-cause death, stroke, MI and repeat revascularization) was
significantly higher for PCI (23.3 percent as compared to 16.4 percent for
CABG, p=0.0002), driven largely by the anticipated higher rate of
revascularization in the PCI group (17.4 percent as compared to 8.6 percent
for CABG, p(less than)0.0001), with the difference narrowing in the second
year of follow-up. Most patients requiring repeat revascularization in the PCI
group were successfully treated with another PCI.
    The trial results were also analyzed based on the SYNTAX Score, which
demonstrated no statistically significant difference in MACCE for patients in
the lower two terciles - those with low lesion complexity (19.4 percent for
PCI and 17.4 percent for CABG, p=0.63) and moderate lesion complexity (22.8
percent for PCI and 16.4 percent for CABG, p=0.06). For patients in the upper
tercile - those with the most complex disease - there was a significant
increase in MACCE for PCI patients as compared to CABG (28.2 percent as
compared to 15.4 percent, p=0.001).
    The SYNTAX Score is a novel angiographic tool used to measure the
complexity of coronary artery disease based on nine anatomic criteria,
including lesion frequency, complexity and location. Higher SYNTAX Scores
indicate patients with more complex disease and increased treatment
challenges. A SYNTAX Score website,, was launched in May
and allows cardiologists and cardiac surgeons to characterize a patient's
anatomical complexity, which can be used in combination with a physician's
clinical judgment to help determine the best revascularization option.
    The SYNTAX Score and SYNTAX Score website were developed under the
direction of the SYNTAX trial steering committee, chaired by Patrick Serruys,
M.D., Ph.D and F.W. Mohr, M.D., Ph.D., and were made possible by support from
Boston Scientific and Cardialysis BV.
    The safety and effectiveness of the TAXUS Express Stent System has not
been established in patients with left main or three-vessel disease.

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    (C)2009 Angiotech Pharmaceuticals, Inc. All Rights Reserved.

    About Angiotech Pharmaceuticals

    Angiotech Pharmaceuticals, Inc. is a global specialty pharmaceutical and
medical device company with over 1,500 dedicated employees. Angiotech
discovers, develops and markets innovative treatment solutions for diseases or
complications associated with medical device implants, surgical interventions
and acute injury. To find out more about Angiotech (NASDAQ:   ANPI, TSX: ANP),
please visit our website at

For further information:

For further information: Irma Gomez-Dib, Investor Relations and
Corporate Communications, Angiotech Pharmaceuticals, Inc., (212) 850-5761,; Sharrifah Al-Salem, Investor Relations and Corporate
Communications, Angiotech Pharmaceuticals, Inc., (415) 293-4414,

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