Angiotech Pharmaceuticals, Inc. - New study shows that Zilver(R) PTX(TM) effectively treats blockages in critical thigh artery

    VANCOUVER, April 14 /CNW/ - Angiotech Pharmaceuticals, Inc. (NASDAQ:  
ANPI, TSX: ANP) today announced its corporate partner, Cook Medical, reported
data on two-year follow up that showed that 82 percent of patients who were
treated with Cook Medical's Zilver(R) PTX(TM) drug-eluting peripheral stent
(DES) were free from reintervention at two-year follow up. The Zilver PTX
Registry study, involving 792 patients from across the world, is assessing the
safety and efficacy of the Zilver PTX in treating PAD. The most recent results
were reported at the 31st International Symposium: Charing Cross Controversies
Challenges Consensus.
    "These results are extremely encouraging as it's the first time
paclitaxel-coated stents have been used in the treatment of blockages in
arteries outside the heart," said Zilver PTX global principal investigator,
Dr. Michael Dake, Professor in the Department of Cardiothoracic Surgery at
Stanford University Medical School and Medical Director of the Cath/Angio
Laboratories at Stanford University Medical Center. "Patients treated with the
Zilver PTX had a very low complication rate and required fewer
    Data was compiled at 12 and 24 months for 593 patients and 177 patients
respectively from the registry study, which enrolled a broad spectrum of
patients, including those with complex lesions (e.g., long lesions, total
occlusions, in-stent restenosis). The corresponding event-free survival (EFS)
rates were 87 percent and 78 percent, and freedom from TLR (target lesion
revascularization) was 89 percent and 82 percent. Clinical measures that
included ankle-brachial index, Rutherford score, and walking distance and
speed scores showed significant improvement at six and 12 months and were
maintained through 24 months.
    Detailed evaluation of stent x-rays demonstrated excellent stent
integrity through 12 months, confirming previously published results showing
99 percent completely intact stents with a mean follow up of 2.4 years in the
challenging superior femoral artery and popliteal arteries, including behind
the knee locations.
    One in five in the 65- to 75-year-old age group in the UK(*) has peripheral
arterial disease (PAD). Yet only a quarter of these people have any symptoms
at all. The 'silent' nature of this condition can result in a number of
patients being diagnosed only when their condition has progressed to the
severe stage. In patients with severe PAD whose condition is not improving
with risk-factor modification, exercise programs and pharmacological therapy,
invasive procedures may need to be carried out. These procedures include
angioplasty, stenting or surgery.
    "We are impressed with both the efficacy and durability demonstrated by
the Zilver PTX in the registry study and believe we will see similar results
in the US randomized trial which is currently ongoing," said Dr. Bill Hunter,
President and CEO of Angiotech. "Our partner, Cook Medical, has been committed
to continually improving the efficacy and safety of peripheral DES and early
results suggest that the self-expanding, Zilver PTX stent will be an important
treatment option for patients with PAD."
    In addition to the registry arm of the study, the 480 patient randomized
component is designed to evaluate the Zilver PTX across 45 trial sites in the
United States, Japan and Europe. Of the 480 patients enrolled in the
randomized study, 240 received the Zilver PTX DES. Enrollment in the
randomized study was completed in 2008. For more information, please visit

    (*) Fowkes FGR, Housley E, Cawood EHH, MacIntyre CAA, Ruckley CV,
    Prescott RJ. Edinburgh artery study: prevalence of asymptomatic and
    symptomatic peripheral arterial disease in the general population. Int J
    Epidemiol 1991;20:384-91.

    Cook licenses the rights to use paclitaxel with peripheral stents and
other non-coronary medical devices from Angiotech. Under the terms of its 1997
license agreement with Cook, Angiotech is entitled to ereceive royalty
payments upon the commercial sale of paclitaxel-eluting peripheral vascular
products, including the Zilver PTX.

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and clinical product development processes; adverse findings related to the
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applicable Canadian regulatory authorities. For a more thorough discussion of
the risks associated with our business, see the "Risk Factors" section in our
annual report for the year ended December 31, 2008 filed with the SEC on Form

    Given these uncertainties, assumptions and risk factors, readers are 
cautioned not to place undue reliance on such forward-looking statements.
Except as required by law, we disclaim any obligation to update any such
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    (C)2009 Angiotech Pharmaceuticals, Inc. All Rights Reserved.

    About Angiotech Pharmaceuticals

    Angiotech Pharmaceuticals, Inc. is a global specialty pharmaceutical and
medical device company with over 1,500 dedicated employees. Angiotech
discovers, develops and markets innovative treatment solutions for diseases or
complications associated with medical device implants, surgical interventions
and acute injury. To find out more about Angiotech (NASDAQ:   ANPI, TSX: ANP),
please visit our website at

For further information:

For further information: DeDe Sheel, Investor Relations and Corporate
Communications, Angiotech Pharmaceuticals, Inc., (415) 293-4412,

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