Aminorex Racehorse Mystery Clarified

    AURORA, Ohio, March 17 /CNW/ -- Over the past 2 + years, racehorses
(principally Standardbreds) have tested positive for the amphetamine,
Aminorex. This drug is a Class 1 substance, where positives result in a 1-5
year suspension from racing. Progressively, rumors have circulated that
certain products may incorporate an ingredient that is not on the label,
including Freedom Health's product: SUCCEED(R) Digestive Conditioning
Program(R) ["SUCCEED"].
    Freedom Health employed a federally accredited analytical toxicology
laboratory to conduct independent, random sampling of SUCCEED and analyze
these samples using LC/MS/MS analytical procedures for the presence of
Aminorex. These LC/MS/MS procedures are the standard procedures used by the
federal government and racing commissions for the detection of Aminorex in
biological samples.
    The LC/MS/MS analysis of random samples of SUCCEED, both oral paste and
granular forms, were NEGATIVE for the presence of Aminorex.
    In an effort to further elucidate the reasons behind the rash of Aminorex
positives in the horse racing community, Freedom Health has learned the

    1) Using the same LC/MS/MS standard procedures for the detection of
       Aminorex, when a commonly used over the counter anthelmetic,
       injectable levamisole phosphate, is assayed directly from the original
       container, the laboratory reported that it contains a substance that
       has a similar molecular weight to Aminorex. However, it has a
       different extraction time, which indicates that it is NOT Aminorex.
       Other commercially available products, including the non-injectable
       forms of levamisole, were NOT found to contain this same compound
       using the same analytical LC/MS/MS procedures.

    2) When horses were administered a variety of commercially available
       wormers and urinalysis was conducted by the laboratory using LC/MS/MS
       procedures for the detection of Aminorex, it reported that the
       aforesaid compound was only detected in the urine of horses
       administered injectable levamisole phosphate. Additionally, laboratory
       results showed two other compounds were detected only in the urine of
       horses administered injectable levamisole phosphate. These two
       additional compounds have the same molecular weight as Aminorex, but
       only one of these compounds had an identical extraction time to
       Aminorex, indicating a potential positive result for detection of

    3) Using GC/MS analytical techniques to further elucidate the exact
       chemical structure of this potential Aminorex compound, laboratory
       analysis found that this compound was Aminorex.

    4) Laboratory results indicate that the levels of Aminorex in urine from
       horses administered injectable levamisole phosphate parallel those
       reported in past and current positive results as handed down by racing

    To summarize, the laboratory results indicate that in our study ONLY the
horses receiving the injectable levamisole phosphate product, either orally or
intramuscularly, resulted in an Aminorex positive result. Aminorex was NOT
found in the product itself, only in the urine of treated horses after
administration of this product, and never in the urine of horses receiving
other anthelmetic products.
    John Hall, President and CEO of Freedom Health LLC said "It was vital
that we not only exonerate SUCCEED, but also that we determine the true cause
of these positives to dispel any residual innuendoes. Dr. Franklin L.
Pellegrini, Vice-President of Veterinary Affairs, has combined his
investigatory analyses of the past two years with the independent analysis of
one of the most highly regarded analytical toxicology teams in the country to
finally resolve this conundrum: Petra G. Hartmann, Director, Drug Testing
Services, and her colleagues at The Industrial Laboratories Company Inc. On
February 1, 2007, we invited Ohio State Racing Commission to monitor this
independent analysis before we commenced. After due consideration at the
highest levels, they declined on February 5."
    Dr. Frank Pellegrini said "Friends, colleagues and erstwhile clients have
sought my help when caught in the Aminorex test 'trap.' It has made absolutely
no sense that reputable trainers would deliberately use a Class 1 substance,
where the recommended penalty effectively results in a loss of livelihood;
much less continue to do so when a valid test exists for this drug. For two
years, I have attempted to identify a common thread. My investigations became
more urgent as progressive rumors circulated that SUCCEED could be the
culprit. Finally, in January, I believed I had identified this common factor.
It then became imperative that any testing be independent, by the most capable
team in the United States. I therefore approached Petra Hartmann with my
concerns, and asked that she test SUCCEED, and my suspect materials. I chose
The Industrial Laboratories Inc., because Ms. Hartmann is the vice-chair of
the Association of Racing Commissioners International Testing Integrity
Program. We received the final report today. I am delighted that we can be a
part of resolving this matter for the overall benefit of horse racing in both
the USA and Canada."

For further information:

For further information: Scott Carter, PhD, +1-330-562-0888 ext. 107,, for Freedom Health

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