50 Millionth Unique Chemical Substance Recorded in CAS REGISTRY(SM)

    Novel analgesic marks major milestone in scientific discovery

    COLUMBUS, Ohio, Sept. 8 /CNW/ -- Chemical Abstracts Service (CAS), a
division of the American Chemical Society, announced that on September 7 it
recorded the 50 millionth substance in CAS REGISTRY, the world's most
comprehensive and high-quality compendium of publicly disclosed chemical
information. The recently registered substance is a novel arylmethylidene
heterocycle with analgesic properties. Reaching the 50 million mark so quickly
is an indicator of the accelerating pace of scientific knowledge. CAS
registered the 40 millionth substance just nine months ago - in contrast, it
took 33 years for CAS to register the 10 millionth compound in 1990.

    Information professionals and scientists around the world have taken note
of this important milestone." The rapid growth of CAS REGISTRY is a mirror of
the breadth and depth of creativity in research labs throughout the world,"
said Grace Baysinger, head librarian at the Swain Chemistry and Chemical
Engineering Library at Stanford University. "CAS REGISTRY is an indispensable
resource for users in research, education, and industry."

    "Achieving a milestone of 50 million small molecules registered, which I
congratulate CAS for, has given us two major insights; one is that a novel
substance is either isolated or synthesized every 2.6 seconds on the average
during the past 12 months, day and night, seven days a week in the world,
showing an almost unbelievable rate of progress in science," said Dr. Hideaki
Chihara, Ph.D. chemist and former president of Japan Association for
International Chemical Information. "The other is that CAS is maintaining its
reputation as the world's largest compilation of substance information that
every scientist in the world relies on either directly or indirectly."

    REGISTRY is the only integrated collection of chemical information from a
full range of patent and journal literature, plus Web and other commercial
sources that is curated and quality-controlled by a global team of scientists.
REGISTRY not only provides chemical names, the unique CAS Registry Number  ,
and vital literature references, but also ancillary information such as
experimental and predicted property data (boiling and melting points, etc.),
commercial availability, preparation details, spectra, and regulatory
information from international sources.

    The 50 millionth substance (CAS Registry Number 1181081-51-5) was
uncovered by CAS scientists from the Examples section of a nearly 200-page
patent issued by the World Intellectual Property Organization on August 13,
2009.  According to the patent, "Few therapeutics are approved by the US Food
and Drug Administration and other regulatory agencies for the treatment of
neuropathic pain."  To address this concern, a series of novel arylmethylidene
heterocycles were synthesized, which included the most recent substance
registered by CAS.

    "The 50 million substances in CAS REGISTRY have the potential to enable
new discoveries in every field of scientific study, from cancer research to
the development of new consumer goods, the creation of more effective drugs,
or the discovery of faster and smaller computer processors,"  said Dr. Matthew
Toussant, senior vice president of editorial operations at CAS. "Scientific
discoveries build upon past discoveries, and it is the quality and
comprehensiveness of CAS REGISTRY that enables chemistry innovation."

    CAS REGISTRY is available to scientists through CAS' award-winning
product, SciFinder , and its STN  family of products. With these advanced
search and analysis technologies, CAS helps scientists find reliable
information that is vital to their research process.

    About CAS
    CAS, a division of the American Chemical Society, provides the world's
largest and most current collection of chemical and related scientific
information, including the most authoritative database of chemical substances,
the CAS REGISTRY(SM). CAS combines these databases with advanced search and
analysis technologies to deliver the most complete, cross-linked, and
effective digital information environment for scientific research and
discovery, including such products as SciFinder, STN, STN Express , and STN 
AnaVist(TM), among others.


For further information:

For further information: Crystal Poole Bradley, +1-614-447-3611,
cas-pr@cas.org Web Site: http://www.cas.org

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