Challenge Calls for Ideas for Glucose-Responsive Insulin Drug, Will Transform Quality of Life for Patients
WALTHAM, MA, Sept. 8, 2011 /CNW/ - The Juvenile Diabetes Research Foundation (JDRF), the worldwide leader for research to cure, treat, and prevent
type 1 diabetes, and InnoCentive, Inc., the pioneer in open innovation and crowdsourcing, today announced a
$100,000 Challenge calling for innovative ways to approach the
discovery and development of a glucose-responsive insulin drug as a
means to treat insulin-dependent diabetes. The Challenge is open to the
public and can be found on the InnoCentive website at https://www.innocentive.com/ar/challenge/9932818.
JDRF is harnessing InnoCentive's Challenge Platform and Global Solver
Community to uncover solutions for a transformative and sophisticated
insulin drug for patients with diabetes, to improve glucose control,
decrease or eliminate the need to test or monitor blood glucose levels,
and reduce their chances of short- and long-term diabetic
complications. Further background on the Challenge can be found on the
InnoCentive website: https://www.innocentive.com/help-jdrf-combat-diabetes.
Through this challenge, JDRF's ultimate goal is to discover a
glucose-responsive insulin drug that would work only when the body
needs it. Glucose-responsive insulin would deliver the precise amount
of insulin needed in response to circulating glucose levels and to
control and maintain normal blood glucose levels throughout a daily
routine with once-daily or less frequent dosing in people with
"Today, insulin treatment requires diligent monitoring and burdensome
administration, often several times a day, every day. This remains the
only way to regulate blood sugar levels for the millions of individuals
with insulin-dependent diabetes worldwide. Although research has
propelled the development of better and faster-acting insulins, the
disease is still hard to control because of the way insulin is
administered to patients," said Aaron Kowalski, Ph.D., assistant Vice
President of Treatment Therapies at JDRF.
"What we need is sophisticated insulin that will take the guesswork out
of managing diabetes by developing a novel insulin that works in the
same way insulin works in people without diabetes," Dr. Kowalski
continued. By fostering novel approaches from diverse problem Solvers
within and outside the diabetes field, we hope this Challenge with
InnoCentive will help speed progress toward the development of
glucose-responsive insulin—progress urgently needed by people with
Type 1 diabetes is an autoimmune disease in which the body's immune
system mistakenly attacks the insulin-producing beta cells in the
pancreas, causing dependence on injected or pumped insulin for life. As
a result, people with type 1 diabetes, as well as some people with
insulin-dependent type 2 diabetes, must currently test their blood
sugar levels and administer insulin through injections or a pump,
sometimes multiple times every day. Yet even with that intensive care,
today's insulin treatments are sub-optimal, and blood sugar levels are
often too high (hyperglycemia) or too low (hypoglycemia), resulting in
life-threatening complications such as kidney failure, blindness, heart
disease, stroke, and amputation.
Hundreds of millions of people in the world are dependent on insulin
(both type 1 and type 2 diabetes). Diabetes represents a major health
risk factor and is one of the leading causes of death worldwide.
Furthermore, it presents a serious economic issue. Global healthcare
expenditures to treat and prevent diabetes and its complications were
estimated to be at least $376 billion in 2010.1
"JDRF is an organization that recognizes the importance of innovation in
the healthcare industry," said Dwayne Spradlin, president and CEO of
InnoCentive. "This approach of looking beyond traditional researchers
to gain new insights, ideas, and solutions illustrates their commitment
to finding a better way to treat diabetes. We are excited to be
partnering with JDRF finding new ways to enhance the quality of life
for patients while helping patients better manage their disease."
In recent months, InnoCentive's unique approach to problem solving has
led to numerous healthcare solutions, including the identification of a biomarker for ALS, a new delivery method for folic acid to women in third world countries, and a new approach to encourage community behavior to help chronically ill teens manage their own health.
This Challenge is open to anyone with a solution that fits the published
criteria, and requires only a written proposal. Submissions for this
Challenge will be accepted through November 9, 2011.
The winning solution from this Challenge could be further developed into
a second phase, named the preclinical proof of principle "Validation
phase." This second phase would require a detailed research plan
proposal, and could offer the winning Solver(s) the opportunity to
become a member(s) of the team created to put the winning solution into
JDRF is the worldwide leader for research to cure type 1 diabetes (T1D).
It contributes to the global agenda for diabetes research, and is the
largest charitable funder and advocate of diabetes science worldwide.
The mission of JDRF is to find a cure for diabetes and its complications
through the support of research. T1D is an autoimmune disease that
strikes children and adults suddenly, and can be fatal. Until a cure is
found, people with T1D have to test their blood sugar and give
themselves insulin injections multiple times or use a pump—each day,
every day of their lives. And even with that intensive care, insulin is
not a cure for diabetes, nor does it prevent its potential
complications, which may include kidney failure, blindness, heart
disease, stroke, and amputation.
Since its founding in 1970 by parents of children with T1D, JDRF has
awarded more than $1.5 billion to diabetes research, including $107
million last year. More than 80 percent of JDRF's expenditures directly
support research and research-related education. For more information,
please visit www.jdrf.org.
InnoCentive is the open innovation and crowdsourcing pioneer that
enables organizations to solve their key problems by connecting them to
diverse sources of innovation including employees, customers, partners,
and the world's largest problem solving marketplace. InnoCentive's
proven Challenge Driven Innovation methodology, community of millions
of problem Solvers, and cloud-based technology platform combine to
fundamentally transform the economics of innovation and R&D through
rapid solution delivery and the development of sustainable open
innovation programs. Leading commercial, government, and nonprofit
organizations such as Eli Lilly, Life Technologies, NASA, nature.com,
Popular Science, Procter & Gamble, Roche, Rockefeller Foundation, and
The Economist partner with InnoCentive to solve problems and innovate
faster and more cost effectively than ever before. For more
information, visit www.innocentive.com.
SOURCE Juvenile Diabetes Research Foundation
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