What's Worse - Swimming with Sharks or Having Travellers' Diarrhea on Vacation?

~ Canadians fear the emotional and financial implications of contracting
travellers' diarrhea on vacation, survey reveals ~

TORONTO, Nov. 16, 2011 /CNW/ - What do swimming with sharks, having a severe sunburn, seeing cockroaches in your hotel room and losing your luggage all have in common?  According to the "State of Vacation: Canadians' Perspectives on Travellers' Diarrhea" survey conducted by Leger Marketing, 73 per cent of respondents would rather experience any of these vacation "downers" than contract travellers' diarrhea.1 Although more than three-quarters of Canadians would get a vaccine to protect against travellers' diarrhea, only one in five are aware a preventative vaccine is available.1

The survey revealed that one-in-three Canadian vacationers have experienced, or have travelled with someone who has experienced, travellers' diarrhea.1  Canadians travelling to Mexico and the Caribbean are at risk of travellers' diarrhea,2 a common medical condition caused by bacteria found in contaminated food and/or transmitted by water3 that can leave individuals bed-ridden.4 Survey respondents indicate that not being able to enjoy time with friends and family (35 per cent) and wasting the money spent on vacation (24 per cent) ranked among their biggest concerns about having travellers' diarrhea.5

"Hindsight is 20/20.  Patients often tell me how their vacations were ruined due to travellers' diarrhea - yet they could have protected themselves," said Dr. Brian Aw, Canadian physician specializing in travel health. "When planning a vacation to a tropical destination this winter travel season, Canadians should understand the potential risk factors associated with these locations, and take preventative measures, like speaking to a healthcare professional about Dukoral®, so they can have a healthy and enjoyable trip.  Dukoral® is an oral vaccine indicated for the prevention of and protection against travellers' diarrhea and/or cholera."

The Impact of Travellers' Diarrhea on Vacation
The condition is characterized by the sudden onset of symptoms that include abdominal pain and diarrhea.6  These symptoms can occur so suddenly that almost 10 per cent of Canadians indicate that when travellers' diarrhea struck they were, "far away from a restroom, making for a difficult situation."  Fifty-five per cent of respondents indicate that, "luckily, we were in the hotel room and had privacy, when the symptoms hit."7

Sources of enterotoxigenic Escherichia coli (ETEC) bacteria, which cause the majority of cases of travellers' diarrhea,8 can include poorly cooked meat, contaminated raw vegetables or unpasteurized dairy products, and no food group can be regarded as "safe".9 A rule of thumb is to either cook it, boil it, peel it - or leave it.10 Of those survey respondents who have had travellers' diarrhea, the main sources of the bacteria were identified as vegetables rinsed with tap water (57 per cent), ice cubes (50 per cent), slushy cocktails (26 per cent) and unpeelable fruit (33 per cent).11

"Learn how to protect yourself from travellers' diarrhea when you start planning for vacation this winter travel season - and this can begin before you get to your destination," said Dr. Aw.  "Speak with a healthcare professional about how to prevent travellers' diarrhea with Dukoral®, which is available with or without a prescription.  It is administered orally as a drink, taken in two doses with the first dose at least two weeks before departure, and protects against travellers' diarrhea for three months."

Dukoral® is an oral, inactivated vaccine indicated for the prevention of and protection against travellers' diarrhea and/or cholera in adults and children two years of age and older who will be visiting areas where there is a risk of contracting travellers' diarrhea caused by ETEC bacteria, or cholera caused by V. cholerae.12

About Travellers' Diarrhea
Travellers' diarrhea is characterized by the sudden onset of symptoms including fever, nausea, vomiting, abdominal pain and diarrhea,13 and affects about one-half of travellers who visit Mexico, the Caribbean, Africa, Southeast Asia, Latin America, Eastern or Southern Europe during a two-week stay.14,15  The condition is caused by bacteria found in contaminated food and/or transmitted by water.16  Bacterial enteropathogens, such as ETEC, cause approximately 80 per cent of cases.17

About Dukoral®
Dukoral® is an oral, inactivated vaccine indicated for the prevention and protection against travellers' diarrhea and/or cholera.  Dukoral® induces the body to make antibodies against the bacteria and toxins, strengthening the body's own defense system.  The liquid Dukoral® vaccine is added to the mixture of water and the powder that is provided with the vaccine, and is taken orally. Protection against ETEC diarrhea and cholera can be expected about one week after the primary immunization series is completed.

Important Safety Information
Dukoral® is intended to help prevent travellers' diarrhea caused by ETEC and/or cholera in adults and children two years of age and older. It does not treat travellers' diarrhea once it develops. Not everyone who gets vaccinated will be fully protected; therefore, precautions to avoid contaminated food or water should be taken. Side effects may include gastrointestinal upsets, such as abdominal pain, diarrhea, nausea or vomiting, due to the bicarbonate buffer used with this vaccine, and allergic reactions may occur. Visit dukoralcanada.com for complete information.

About Crucell Vaccines N.V.
Crucell Vaccines N.V. (Crucell) is a global biopharmaceutical company focused on research development, production and marketing of vaccines, proteins and antibodies that prevent and/or treat infectious diseases.  In 2010 alone, Crucell distributed more than 105 million vaccine doses in more than 100 countries around the world. Crucell is one of the major suppliers of vaccines to UNICEF and the developing world.  Products in Crucell's core portfolio include a fully-liquid pentavalent vaccine, Quinvaxem®, a vaccine against hepatitis B and a virosome-adjuvanted vaccine against influenza.  Crucell also markets travel vaccines, such as an oral anti-typhoid vaccine, an oral cholera vaccine and the only aluminum-free hepatitis A vaccine on the market.  For more information, please visit www.crucell.com.

About the "State of Vacation: Canadians' Perspectives on Travellers' Diarrhea" Survey
The "State of Vacation: Canadians' Perspectives on Travellers' Diarrhea" survey, conducted by Leger Marketing in October 2011, included an online poll of 1,001 Canadians. A probability sample of the same size would yield a margin of error of +/-3.1 per cent, 19 times out of 20.  The survey was funded by Crucell Vaccines N.V.

For more information, please visit dukoralcanada.com.

References:
_____________________

1 State of Vacation:  Canadians Perspectives on Travellers' Diarrhea.  Leger Marketing.  October 2011.

2 Public Health Agency of Canada. Travellers' Diarrhea.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/tmp-pmv/info/diarrhea-eng.php

3 Public Health Agency of Canada. Statement on New Oral Cholera and Travellers' Diarrhea Vaccination.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/asc-dcc-7/index-eng.php

4 Public Health Agency of Canada. Statement on New Oral Cholera and Travellers' Diarrhea Vaccination.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/asc-dcc-7/index-eng.php

5 State of Vacation:  Canadians Perspectives on Travellers' Diarrhea.  Leger Marketing.  October 2011.

6 Public Health Agency of Canada. Travellers' Diarrhea.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/tmp-pmv/info/diarrhea-eng.php

7 State of Vacation:  Canadians Perspectives on Travellers' Diarrhea.  Leger Marketing.  October 2011.

8 Public Health Agency of Canada. Statement on New Oral Cholera and Travellers' Diarrhea Vaccination.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/asc-dcc-7/index-eng.php

9 Public Health Agency of Canada. Statement on New Oral Cholera and Travellers' Diarrhea Vaccination.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/asc-dcc-7/index-eng.php

10 Public Health Agency of Canada.  Communicable Disease Report Vol. 27 March 15, 2011. Statement on Travellers' Diarrhea.  Accessed October 18, 2011.

11 State of Vacation:  Canadians Perspectives on Travellers' Diarrhea.  Leger Marketing.  October 2011.

12 DUKORAL® Product Monograph 2011.

13 Public Health Agency of Canada. Travellers' Diarrhea.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/tmp-pmv/info/diarrhea-eng.php

14 Public Health Agency of Canada. Travellers' Diarrhea.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/asc-dcc-7/index-eng.php

15 Public Health Agency of Canada. Statement on New Oral Cholera and Travellers' Diarrhea Vaccination.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/tmp-pmv/info/diarrhea-eng.php

16 Public Health Agency of Canada. Statement on New Oral Cholera and Travellers' Diarrhea Vaccination.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/asc-dcc-7/index-eng.php

17 Public Health Agency of Canada. Statement on New Oral Cholera and Travellers' Diarrhea Vaccination.  Accessed September 21, 2011.  http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/05vol31/asc-dcc-7/index-eng.php


SOURCE Crucell Vaccines N.V.

For further information:

For more information or to arrange an interview, please contact:
Laine Jaremey
GCI Group (Canada)
416-486-7224
laine.jaremey@gcicanada.com

Kate Hanna
Crucell Vaccines N.V.
416-382-5017
Khanna7@its.jnj.com

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