The Leukemia & Lymphoma Society and Aegera Therapeutics Announce Collaboration to Open Clinical Trial



    WHITE PLAINS, N.Y., June 11 /CNW/ -- Aegera Therapeutics Inc. and The
Leukemia & Lymphoma Society (LLS) today jointly announced the execution of an
agreement for $3.3 million (U.S.) to support an international Phase I/II
clinical trial. The trial is for Aegera's AEG35156, a targeted therapy for
blood cancer patients with follicular lymphoma (FL), small lymphocytic
lymphoma and chronic lymphocytic leukemia (CLL).
    "CLL and FL, collectively, represent approximately 30 percent of the more
than 73,000 non-Hodgkin lymphoma cases diagnosed annually in the United States
and Canada," said Louis J. DeGennaro, Ph.D., LLS chief scientific officer.
"Current conventional therapy is non-curative in these patient populations.
Our goal is to bring new therapies to patients.  The partnership with Aegera
accelerates the clinical testing of a novel blood cancer therapy and brings us
closer to that goal."
    
    The clinical trials will take place in Canada and the United States.
    
    "We are very honoured to have been selected by LLS to support our novel
therapeutic approach to potentially treat CLL and FL," said Michael J.
Berendt, Ph.D., president and CEO, Aegera Therapeutics. "AEG35156 is a second
generation antisense compound that targets the knockdown of XIAP, a key
inhibitor of apoptosis in cancerous cells. This funding greatly enhances our
ability to quickly test the effectiveness of this innovative targeted therapy
in clinical trials."
    The agreement marks the first clinical trial announced under LLS's
Therapy Acceleration Program, an innovative program designed to advance
therapies with high prospects of providing near-term benefit to patients
suffering from blood cancers.
    
    About Aegera Therapeutics Inc.
    
    Aegera Therapeutics is a well-funded, clinical-stage, Canadian
biotechnology company focused on developing drugs that control apoptosis to
address major, unmet medical needs.  Aegera has four programs in clinical
development for oncology and pain, including AEG35156, a second-generation
antisense compound that targets the knockdown of XIAP, a key inhibitor of
apoptosis in cancerous cells.  Details of Aegera's programs can be viewed at
www.aegera.com.
    
    About The Leukemia & Lymphoma Society
    
    The Leukemia & Lymphoma Society(R), headquartered in White Plains, NY,
with 68 chapters in the United States and Canada, is the world's largest
voluntary health organization dedicated to funding blood cancer research and
providing education and patient services. The LLS mission: Cure leukemia,
lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of
patients and their families. Since its founding in 1949, LLS has invested more
than $550 million in research specifically targeting leukemia, lymphoma and
myeloma. Last year alone, LLS made 5.1 million contacts with patients,
caregivers and healthcare professionals.
    For more information about blood cancer, visit www.LLS.org or call the
LLS Information Resource Center (IRC), a call center staffed by master's level
social workers, nurses and health educators who provide information, support
and resources to patients and their families and caregivers. IRC information
specialists are available at (800) 955-4572, Monday through Friday, 9 a.m. to
6 p.m. ET.


    
     LLS Contact: Andrea Greif           Aegera Contact: Catherine So
     914.821.8958                        514.288.4091 (225)
     andrea.greif@lls.org                catherine.so@aegera.com
    




For further information:

For further information: LLS Contact, Andrea Greif, +1-914-821-8958, 
andrea.greif@lls.org; or Aegera Contact, Catherine So, +1-514-288-4091 (225), 
catherine.so@aegera.com Web Site: http://www.LLS.org                 
http://www.aegera.com

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THE LEUKEMIA & LYMPHOMA SOCIETY

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AEGERA THERAPEUTICS INC.

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