Protox completes enrollment of Phase 2 BPH trial



    VANCOUVER, Sept. 3 /CNW/ - Protox Therapeutics Inc. (TSX:PRX), a leader
in the development of receptor targeted fusion proteins, announced today that
it has completed enrollment of patients for its Phase 2 study of PRX302 in
males with moderate to severe benign prostatic hyperplasia (BPH), a common and
bothersome urological condition that affects more than 1 million men in Canada
and over 50 million men worldwide.
    "Protox is very pleased to have completed this clinical trial ahead of
schedule and looks forward to releasing top line data from this study in the
fourth quarter of 2008," said Dr. Fahar Merchant, President and CEO of Protox.
"The results from the company's Phase 1 BPH study demonstrated that PRX302 has
an excellent safety and tolerability profile and also showed substantial
symptomatic benefit in the majority of patients treated. This Phase 2 study
will provide Protox with valuable information as we continue to advance this
exciting project that we believe has the potential of establishing a new
standard of care for this disease."

    About BPH

    BPH is a common urological condition characterized by painful and
bothersome symptoms that include difficulty in initiating a urine stream, a
sense of urgency, leaking, dribbling and presence of blood in the urine. The
condition affects over 50 million men throughout North America, Europe and
Japan. More than half of all men will have symptoms of BPH by age 60 and as
many as 90 percent may suffer from BPH after the age of 70. Current drug
therapies only provide symptomatic relief and may trigger a range of side
effects including impotence and hypotension. Surgical options such as TURP
(transurethral resection of the prostate), which constitute the second-largest
item in the US Medicare budget, can cause impotence, incontinence and other
more serious procedure-related effects. According to Wood Mackenzie (2007),
the market opportunity for therapies used to treat BPH was US $5.5 billion in
drug therapies and US $4 billion in surgical procedures.

    About PRX302

    PRX302 is the lead drug candidate in the company's PORxin(TM) technology
platform. PORxin drugs are pro-drugs that are activated by specific proteases
produced at elevated levels on the surface of target cells. PRX302 has been
generated by engineering the naturally occurring toxin proaerolysin to create
a potent agent with a distinct mode of action. The drug has been engineered so
that it is activated by prostate-specific antigen (PSA), an enzyme that is
overproduced in patients suffering from prostate cancer and BPH (benign
prostatic hyperplasia or enlarged prostate). Once activated, the drug punches
holes in the target cells causing the contents to leak out and ultimately cell
death.

    About Protox

    Protox Therapeutics is a leader in advancing novel, receptor targeted
fusion proteins. Two novel drug candidates derived from the company's
INxin(TM) and PORxin(TM) platforms are being developed in three clinical
programs. A Phase 2a clinical trial evaluating PRX321 (INxin) for the
treatment of primary brain cancer has been completed and the drug has received
Fast Track Designation and Orphan Drug Status from the US FDA and EMEA. Phase
2a clinical trials evaluating PRX302 (PORxin) for the treatment of localized
prostate cancer and benign prostatic hyperplasia (enlarged prostate) are
ongoing. Protox is also collaborating with the U.S. National Institutes of
Health (NIH) on a research program focused on the discovery of next generation
fully human targeted therapeutics.

    Certain statements included in this press release may be considered
forward-looking. Such statements involve known and unknown risks,
uncertainties and other factors that may cause actual results, performance or
achievements to be materially different from those implied by such statements,
and therefore these statements should not be read as guarantees of future
performance or results. All forward-looking statements are based on Protox'
current beliefs as well as assumptions made by and information currently
available to Protox and relate to, among other things, anticipated financial
performance, business prospects, strategies, regulatory developments, market
acceptance and future commitments. Readers are cautioned not to place undue
reliance on these forward-looking statements, which speak only as of the date
of this press release. Due to risks and uncertainties, including the risks and
uncertainties identified by Protox in its public securities filings; actual
events may differ materially from current expectations. Protox disclaims any
intention or obligation to update or revise any forward-looking statements,
whether as a result of new information, future events or otherwise.





For further information:

For further information: James Beesley, Director, Investor Relations,
Protox Therapeutics, (604) 484-0975, jbeesley@protoxtherapeutics.com; Michael
Moore, Investor Relations, Equicom Group, (416) 815-0700 x 241,
mmoore@equicomgroup.com

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