Preclinical Study Published in Nature Medicine Shows Anti-LINGO-1 Antibody Promotes Remyelination



    Suggests Potential Role in the Treatment of Multiple Sclerosis and Other
Demyelinating Diseases

    CAMBRIDGE, MASS., September 30 /CNW/ - Biogen Idec (NASDAQ:   BIIB)
announced today the publication of findings from a preclinical study reporting
that the anti-LINGO-1 antibody can promote spinal cord remyelination and
axonal integrity, suggesting a potential role as a treatment for multiple
sclerosis (MS) and other demyelinating diseases of the central nervous system
(CNS). The results are published in the October issue of Nature Medicine, and
confirm previously published data that suggested a role for the anti-LINGO-1
antibody in CNS myelin repair.

    LINGO-1 appears to act as a molecular switch that controls the ability of
cells in the CNS to produce myelin, the protective cellular sheath surrounding
nerve fibers that assists nerves in conducting electrical impulses. When
myelin is damaged by autoimmune diseases such as MS, nerve cells lose their
ability to send signals to the body. As this damage progresses, these cells
may eventually die, contributing to disability. Although MS therapies can slow
the progression of this damage, none are able to repair the lost myelin.
Biogen Idec scientists had previously discovered that LINGO-1 may act to
prevent myelin repair after injury. In the study published today, by blocking
LINGO-1, scientists were able to promote myelin repair and improve recovery in
an animal model of MS.

    "While preliminary, these findings are encouraging and suggest that the
anti-LINGO-1 antibody has the potential to repair some of the damage caused to
the CNS. This may be an entirely new approach to treating MS," said Alfred
Sandrock, MD, PhD, Senior Vice President, Neurology Research and Development,
Biogen Idec. "The anti-LINGO-1 program is a key part of our research and
development efforts in MS. We have a diverse pipeline of therapeutic
candidates targeting multiple pathways and patient needs with the goal of
offering a portfolio of options for people living with this devastating
disease."

    In the study, functional recovery from demyelination was modeled by
tracking the disease progression of experimental autoimmune encephalomyelitis
(EAE), a widely accepted animal model for studying the clinical and
pathological features of MS. The anti-LINGO-1 antibody was administered before
disease onset and was found to decrease the severity of EAE across all stages
of disease progression, when compared to the control treatment group. In a
related study, anti-LINGO-1 antibody treatment resulted in significantly
reduced EAE symptoms even when it was administered after disease onset.

    The study found that functional recovery, as measured by EAE scores,
correlated with improved axonal integrity and axonal remyelination.
Physiological improvements in axonal integrity were revealed by magnetic
resonance DTI imaging. At the cellular level, the production of new myelin
sheaths was revealed by histological staining and electron microscopy.

    "This is a very exciting early indication that therapies targeted at
myelin repair within the CNS can have a dramatic effect on behavioral
functional outcome in models of multiple sclerosis, and opens the door for the
identification of additional regulators of myelin repair that might be used to
enhance functional recovery in patients with MS," said Robert H. Miller, PhD,
Principal Investigator, Myelin Repair Foundation and Director of the Center
for Translational Neuroscience, Case Western Reserve University.

    Anti-LINGO-1 was discovered by Biogen Idec and is one of several programs
in the company's industry-leading research and development efforts in MS. In
addition to its two marketed products, the company has four programs in
clinical development for the treatment of MS.

    About Biogen Idec

    Biogen Idec creates new standards of care in therapeutic areas with high
unmet medical needs. Founded in 1978, Biogen Idec is a global leader in the
discovery, development, manufacturing, and commercialization of innovative
therapies. Patients in more than 90 countries benefit from Biogen Idec's
significant products that address diseases such as lymphoma, multiple
sclerosis, and rheumatoid arthritis. For product labeling, press releases and
additional information about the company, please visit www.biogenidec.com.

    Safe Harbor/Forward-Looking Statements

    This press release contains forward-looking statements regarding
anti-LINGO-1 antibody, which is currently in the preclinical stage of drug
development. Drug development involves a high degree of risk. Only a small
number of research and development programs result in commercialization of a
product. Factors which could cause actual results to differ materially from
Biogen Idec's current expectations include the risk that the company may not
be able to demonstrate the safety and efficacy of anti-LINGO-1 antibody at
each stage of the clinical trial process; technical hurdles relating to the
manufacture of anti-LINGO-1 antibody may be encountered; the company may not
be able to meet applicable regulatory standards or regulatory authorities may
fail to approve anti-LINGO-1 antibody; and the company may encounter other
unexpected hurdles. For more detailed information on the risks and
uncertainties associated with Biogen Idec's drug development and other
activities, see the periodic and current reports that the company has filed
with the Securities and Exchange Commission. Biogen Idec assumes no obligation
to update any forward-looking statements, whether as a result of new
information, future events or otherwise.




For further information:

For further information: MEDIA CONTACTS: Biogen Idec Amy Reilly,
617-914-6524 or INVESTOR CONTACTS: Biogen Idec Eric Hoffman, 617-679-2812

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