Paediatric World First - SickKids Team performs lifesaving lung procedure



    16-year-old patient back in action at school and soccer field

    TORONTO, Feb. 17 /CNW/ - In a world first, doctors at The Hospital for
Sick Children (SickKids) performed an innovative operation using an external
artificial lung to keep a paediatric patient alive until new donor lungs were
available.
    Sixteen-year-old Katie Sutherland was temporarily fitted with the
Interventional Lung Assist device or Novalung(R). For 30 days, Katie's blood
circulated externally through a small white box, which enriched her blood with
oxygen, removed carbon dioxide and most importantly for Katie, relieved the
pressure on her heart caused by her sick lungs.
    The SickKids surgical team, led by Dr. Shaf Keshavjee, Director of the
Toronto Lung Transplant Program, used the German-made Novalung(R) device to
partially bypass Katie's failing lungs allowing her heart to do less work.
    Unlike older artificial lungs which were run by mechanical pumps,
Novalung(R) is powered by the patient's own heartbeat. It is a membrane
ventilator that allows oxygen and carbon dioxide to exchange through simple
diffusion.
    Last summer, Katie, then 15, was diagnosed with pulmonary hypertension.
This rare condition constricts veins and arteries within the lungs and forces
the heart to work much harder than normal to pump blood to the lungs. As a
result Katie's heart was failing. Before the operation her heart had swelled
up to four times its regular size and was no longer pumping enough blood.
    "Katie was gravely ill and in fact had a short period of cardiac arrest
in the operating room," says Keshavjee. "She almost certainly would have died
that night. Our procedure helped her stay alive long enough for suitable donor
lungs to become available for transplant."
    The three-hour procedure at SickKids was performed on July 3, 2008, by a
10-member team led by Dr. Keshavjee, Dr. Marc de Perrot and Dr. Andrew Pierre,
SickKids cardiovascular thoracic surgeons. With the artificial lung, Katie
remained stable for a month until suitable donor lungs became available for
her. During that time she was able to breathe, talk and eat, and do gentle
exercises.
    The success of Katie's month-long stint on an artificial lung is
attributable to the coordinated efforts of health-care professionals from
SickKids and Toronto General Hospital (TGH); including respiratory physicians
Dr. Mindy Solomon and Dr. Hartmut Grasemann, critical care physicians,
anesthesiologists, operating room and critical care nurses, respiratory
therapists and cardiovascular perfusionists.
    This is the first time in the world that the Novalung(R) has been used in
this way in a paediatric patient, and only the second time the device has been
applied in this fashion in North America.
    Up to 20 per cent of patients on the lung transplant waiting list die
before a matching lung is found, and patients with pulmonary artery
hypertension are at the highest risk level.
    "We know that Katie's life has been saved, and we are incredibly thankful
to the staff," says Paul Sutherland, Katie's father. "To actually experience a
technological step forward is very humbling."
    Katie, who celebrated her 16th birthday in the Critical Care Unit at
SickKids, returned home with a new pair of lungs. She is finally getting back
into her routine - just recently returning to school and she has just started
playing soccer.

    The Hospital for Sick Children (SickKids), affiliated with the University
of Toronto, is Canada's most research-intensive hospital and the largest
centre dedicated to improving children's health in the country. As innovators
in child health, SickKids improves the health of children by integrating care,
research and teaching. Our mission is to provide the best in complex and
specialized care by creating scientific and clinical advancements, sharing our
knowledge and expertise and championing the development of an accessible,
comprehensive and sustainable child health system. For more information,
please visit www.sickkids.ca. SickKids is committed to healthier children for
a better world.

    Toronto an International Lung Transplant Centre

    The Toronto Lung Transplant Program, a combined adult and paediatric
program based at SickKids and Toronto General Hospital (TGH), University of
Toronto, is a leader in lung transplantation. The first successful single lung
transplant in the world was performed in Toronto in 1983.





For further information:

For further information: Katie, her family and Dr. Keshavjee will be
available to the media on Feb.17 and 18. For more information please contact:
Matet Nebres, The Hospital for Sick Children, (416) 813-6380, e-mail
matet.nebres@sickkids.ca

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