New study to test oral insulin in the prevention of diabetes



    TORONTO, Oct. 16 /CNW/ - Researchers at The Hospital for Sick Children
(SickKids) are leading the Canadian component of a multinational clinical
study aimed at preventing or delaying type 1 diabetes. The Type 1 Diabetes
TrialNet study will examine whether taking insulin orally can prevent or delay
diabetes in people who are at risk for the disease.
    "People who have a first- or second-degree relative with type 1 diabetes
have approximately a 15 times greater risk of developing the disease than the
general population," says Dr. Diane Wherrett, staff endocrinologist at
SickKids and the lead Canadian investigator for the Type 1 Diabetes TrialNet
study for oral insulin. "Our goal is to determine whether taking oral insulin
can help prevent type 1 diabetes or delay it, even for a few years, allowing
those at risk a chance to avoid the challenges of controlling glucose levels
and other serious health complications."
    Type 1 diabetes, usually diagnosed in children, is due to abnormal
autoimmunity that destroys insulin producing cells in the pancreas. Insulin is
an essential hormone that allows the body's cells to use sugar for energy.
Approximately 200,000 Canadians have type 1 diabetes and require daily insulin
injections. Type 1 diabetes hardens small blood vessels and is the leading
cause of blindness, kidney failure, stroke and loss of limbs.
    In this study, researchers will test whether an insulin capsule taken by
mouth once a day can prevent or delay diabetes in a specific group of people
at risk for type 1 diabetes. Some scientists believe that introducing insulin
via the digestive track induces tolerance or a quieting of the immune system's
destruction of cells that produce insulin. In a previous diabetes prevention
trial using oral insulin, a sub-group showed a delay in the onset of type 1
diabetes.
    Approximately 20,000 people per year worldwide who have first- and
second-degree relatives with type 1 diabetes will be recruited for the oral
insulin study over the next five years. Individuals who are between the ages
of three and 45 and have a first-degree blood relative (child, parent or
sibling) or individuals who are between the ages of three and 20 and have a
second-degree blood relative (uncle, aunt, niece, nephew, cousin or
grandparent) with type 1 diabetes may be eligible for screening to determine
their risk of developing this disease. The initial screening involves a single
blood test to look for autoantibodies that may present long before the onset
of diabetes. To enroll in the study or for more information, Canadians can
call 416-813-5858 or 1-866-699-1899 or www.diabetestrialnet.org.
    The national study is led by SickKids, who will coordinate the trial with
10 other centres across Canada: Calgary, Edmonton, Vancouver, Winnipeg, Saint
John, St. John's, Halifax, Hamilton, London and Montreal.
    More than 100 centres across Canada, the United States, Europe and
Australia will be involved in the study. This study is conducted by Type 1
Diabetes TrialNet, a National Institutes of Health (NIH) funded network of
researchers dedicated to the understanding, prevention and early treatment of
type 1 diabetes. The Type 1 Diabetes TrialNet studies are funded by the
National Institute of Diabetes and Digestive and Kidney Diseases, the National
Institute of Child Heath and Human Development, and the National Institute of
Allergy and Infectious Diseases within the NIH. The Juvenile Diabetes Research
Foundation International and the American Diabetes Association also support
this initiative.

    The Hospital for Sick Children (SickKids), affiliated with the University
of Toronto, is Canada's most research-intensive hospital and the largest
centre dedicated to improving children's health in the country. As innovators
in child health, SickKids improves the health of children by integrating care,
research and teaching. Our mission is to provide the best in complex and
specialized care by creating scientific and clinical advancements, sharing our
knowledge and expertise and championing the development of an accessible,
comprehensive and sustainable child health system. For more information,
please visit www.sickkids.ca. SickKids is committed to healthier children for
a better world.

    Please note: The next scheduled screening in Toronto will be held on
November 21 from 4 to 8 pm. SickKids will also be holding screening sessions
in the Greater Toronto Area, as well as in Barrie, Kitchener, Orangeville,
Oshawa and Peterborough. Participants must call in advance to book an
appointment for a screening at 416-813-5858 or 1-866-699-1899.





For further information:

For further information: Lisa Lipkin, Public Affairs, The Hospital for
Sick Children (Sick Kids), tel: (416) 813-6380, lisa.lipkin@sickkids.ca

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