Nature Reviews Publishes Article About Jennerex's Multi-Mechanistic Cancer Therapeutic



    SAN FRANCISCO, Feb. 10 /CNW/ -- Jennerex, Inc. (San Francisco, CA and
Ottawa, Canada) a clinical-stage biopharmaceutical company, announced today
that the journal, Nature Reviews Cancer, has published an article about the
company's promising, targeted and armed oncolytic poxviruses, which have
demonstrated encouraging clinical and preclinical data.  The article,
published in the January 2009 issue, was authored by David H. Kirn, M.D.,
president and chief executive officer of Jennerex and Visiting Professor,
Department of Clinical Pharmacology, University of Oxford, and Steve H.
Thorne, Assistant Professor at the Departments of Surgery and Immunology at
the University of Pittsburgh Cancer Institute.
    "We are honored that Nature Reviews Cancer considers oncolytic poxviruses
to be such an important emerging field as to devote a full Perspectives
Opinion to reviewing major recent advances.  We are excited by the data that
investigators have reported to date with our first-in-class cancer
therapeutics.  The lead product in this class, JX-594, is currently in Phase 2
testing for liver cancer and colorectal cancer.  The Phase 1 intra-tumoral
trial of JX-594 demonstrated objective tumor destruction in most patients,
with multiple types of cancer, and we are now also studying systemic delivery
of JX-594 in the clinic," stated Dr. Kirn.  "Our next product from this class,
JX-929, is now being evaluated in a Phase 1 clinical trial."
    The article reviewed the evolution of the field of oncolytic viral
therapy.  First-generation agents have shown limited efficacy in the past for
technical reasons elucidated by Jennerex investigators.  Previous technical
obstacles have provided valuable information to guide Jennerex toward a
completely new class of novel, oncolytic poxviruses, combining targeted and
armed approaches for treating cancer.  Initial preclinical and clinical
results show that products from this breakthrough therapeutic class can
systemically target cancers in a highly selective and potent fashion using a
multi-pronged mechanism of action.  Jennerex products replicate in cancer
cells, leading to cancer cell destruction, while normal cells are left
unharmed.  The Phase 1 study results were recently published in prestigious
journals Lancet Oncology and Molecular Therapy.
    The poxvirus strain backbone of Jennerex's cancer therapeutics have been
used safely in millions of people as part of a worldwide vaccination program
against smallpox.  This strain naturally targets cancer cells due to common
genetic defects in cancer cells.  The products are activated by genetic
pathways that are critical to the vast majority of human cancers, such as the
EGFR-ras pathway, and they employ a novel primary mechanism-of-action that is
effective even against cancers that are resistant to standard therapies such
as chemotherapy and radiation.  Simultaneously, a therapeutic cascade is
initiated by product replication resulting in tumor vasculature shutdown and
anti-tumoral immune attack.  In addition, these products are "armed" with
immune-stimulatory GM-CSF that destroys cancers by complementary and
synergistic mechanisms.
    "This extensive scientific review examines the huge strides made in the
field of viral therapy over the past 15 years," said Dr. Stephen Thorne,
Assistant Professor at the University of Pittsburgh Cancer Institute and
Coauthor.
    
    About Jennerex
    
    Jennerex is a clinical-stage biopharmaceutical company focused on the
development and commercialization of first-in-class, breakthrough targeted
oncolytic products for cancer. The company's lead product JX-594, currently in
an international Phase 2 trial for primary liver cancer and colorectal cancer,
demonstrated promising Phase 1 efficacy and safety results in patients with a
diverse array of common cancers. Jennerex's products target, attack and
eradicate cancers through a novel and potent oncolytic mechanism that is
dependent on highly-specific replication of the company's poxviruses in cancer
cells. These products simultaneously stimulate the body's immune response to
the cancer. Of note, this mechanism of action and the results in patients to
date put the company's product class in a leadership position. Jennerex's
therapeutic approach is markedly different from gene therapy and standard
cancer vaccine approaches. Jennerex Biotherapeutics was established in San
Francisco, CA and in Ottawa, Canada in 2006, with Dr. David Kirn (CEO) in San
Francisco and Dr. John Bell (CSO) from the Ottawa Health Research
Institute/University of Ottawa. For more information about Jennerex and the
company's robust pipeline and three clinical-stage products, please visit
http://www.jennerex.com.




For further information:

For further information: Jennifer Cook Williams of Cook Williams
Communications, Inc., +1-360-668-3701, jennifer@cwcomm.org, for Jennerex, Inc.
Web Site: http://www.jennerex.com

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