Angiotech and Boston Scientific welcome journal article noting important differences between drug-eluting stent brands



    VANCOUVER, May 11 /CNW/ - Angiotech Pharmaceuticals, Inc. (NASDAQ:   ANPI,
TSX: ANP) today announced its corporate partner, Boston Scientific
Corporation, has welcomed the publication of an article in the current edition
of the Journal of the American College of Cardiology (JACC) reviewing data on
more than 19,000 patients from the Swedish national registry who were
evaluated for restenosis, or the re-narrowing or arteries after percutaneous
coronary intervention (PCI). The article reported that patients who received a
TAXUS(R) Liberté(R) Paclitaxel-Eluting Stent had numerically lower incidences
of repeat procedures to treat restenosis at two years as compared to patients
treated with 'olimus-based drug-eluting stents (DES), including Cordis'
Cypher(R) Stent and Medtronic's Endeavor(R) Stent. In the patients with
diabetes, the TAXUS Liberté Stent demonstrated a statistically significant
lower restenosis rate compared to the Endeavor Stent, which had more than two
times the risk of repeat procedures.
    The Swedish Coronary Angiography and Angioplasty Registry holds data on
all patients undergoing PCI in Sweden. The objective of this independent study
was to evaluate restenosis rates of drug-eluting stents in patients with and
without diabetes in a real-world setting. The JACC article reported that both
the TAXUS Liberté Stent and Boston Scientific's first-generation DES -- the
TAXUS(R) Express(R) Stent -- were the only stents in the study showing no
increased risk of restenosis for patients with diabetes as compared to those
without diabetes. Both the Cypher Stent and Endeavor Stent showed significant
increased risk of restenosis in patients with diabetes. In addition, the study
showed that the TAXUS Liberté Stent had an approximately 23 percent lower
restenosis rate at two years compared to the prior-generation TAXUS Express
Stent. The authors concluded that "There seem to be important differences
between different brands of DES."(1)
    "The results of this study are noteworthy for TAXUS Liberté, which
compared favorably in rates of repeat procedures to both 'olimus stents," said
Donald S. Baim, M.D., Chief Medical and Scientific Officer of Boston
Scientific. "The findings presented in the article are consistent with our own
clinical trial observations, including recently published ARRIVE and ATLAS
data, and may reflect the different mechanism of action for paclitaxel
compared to the 'olimus agents used in the other drug-eluting stents. The
newer and thinner-strut TAXUS Liberté Stent performed better than the TAXUS
Express Stent in reducing restenosis."
    The Swedish registry study included four DES brands: TAXUS Liberté, TAXUS
Express, Cypher and Endeavor. In total, the registry included 35,478 DES
implants during 22,962 procedures in 19,004 patients, with 1,807 restenoses
reported over a mean 29-month follow-up period. For the entire study
population, the repeat revascularization rate per stent was 3.5 percent after
one year and 4.9 percent after two years. Overall, the adjusted risk of
restenosis was 1.23 times higher in patients with diabetes than in patients
without diabetes. In patients with diabetes, restenosis was higher in the
non-TAXUS Stents. The sirolimus-eluting Cypher Stent and the
zotorolimus-eluting Endeavor Stent had higher restenosis rates in patients
with diabetes compared with those in patients without diabetes (1.25 times and
1.77 times, respectively).
    TAXUS Stents have been evaluated by the industry's most extensive
randomized, controlled clinical trial program, with follow-up to five years in
some cases. These trial results have been supplemented by data on more than
35,000 patients enrolled in post-approval registries. To date, approximately
11 million Boston Scientific stents have been implanted globally, making them
the world's most frequently used stents.
    The TAXUS Liberté Paclitaxel-Eluting Coronary Stent System received U.S.
Food and Drug Administration approval in October 2008, and received European
CE Mark approval for use in patients with diabetes in December 2007. In the
U.S., the TAXUS Stents are not specifically indicated for use in patients with
diabetes.

    (1) J Am Coll Cardiol 2009;53:1660-7

    
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    (C) 2009 Angiotech Pharmaceuticals, Inc. All Rights Reserved.

    About Angiotech Pharmaceuticals

    Angiotech Pharmaceuticals, Inc. is a global specialty pharmaceutical and
medical device company with over 1,500 dedicated employees. Angiotech
discovers, develops and markets innovative treatment solutions for diseases or
complications associated with medical device implants, surgical interventions
and acute injury. To find out more about Angiotech (NASDAQ:   ANPI, TSX: ANP),
please visit our website at www.angiotech.com.





For further information:

For further information: DeDe Sheel, Investor Relations and Corporate
Communications, Angiotech Pharmaceuticals, Inc., (415) 293-4412,
dede.sheel@fdashtonpartners.com

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