WELLESLEY, MA, July 3, 2013 /CNW/ - Data obtained in a recent animal
study confirm the potential of a new class of drugs targeted to
Alzheimer's disease and age-related cognitive impairment, with special
promise for patients carrying the APOE4 gene.
Administration of sGC-1061, a member of a class of compounds known as
'nomethiazoles', to E4FAD mice for 10 weeks resulted in a significant
reduction in the levels of soluble (neurotoxic) amyloid-beta (amino
acids 1-42) in the treated animals.
E4FAD mice are a preferred model of Alzheimer's disease, in that they
carry a copy of the human APOE4 gene in place of the mouse APOE gene.
E4FAD mice may be useful for testing for expected efficacy of candidate
Alzheimer's drugs for the subset of people that carry the APOE4 gene.
APOE4 carriers account for more than half of Alzheimer's patients and
the APOE4 genetic polymorphism accelerates disease progression and
onset of cognitive impairment by seven to nine years per gene copy.
Previous published studies on sGC -1061 have demonstrated the compound's
potential to improve synaptic function in the central nervous system in
two other animal models of Alzheimer's disease. Pharmacology and
toxicology data support the potential of the drug, and a prototype
sustained-release formulation is under development. sGC-1061 is poised
to enter Phase 2 evaluation in target populations.
The E4FAD mouse studies were completed in the laboratories of Professors
Mary Jo Ladu and Greg Thatcher, the latter being the inventor of the
class of compounds known as nomethiazoles. Dr. Thatcher began this work
while at Queen's University in Kingston, Ontario, Canada. He now holds
the Hans W. Vahlteich Chair of Medicinal Chemistry in the Department of
Medicinal Chemistry and Pharmacognosy at the University of
Illinois, Chicago. His laboratory continues to work on the development
Dr. Thatcher's work on nomethiazoles has been licensed from Queen's
University's PARTEQ Innovations and the University of Illinois and is
being developed by sGC Pharma Inc. Dr. Doug Cowart of sGC Pharma has
indicated that the formulation of sGC-1061 relies on recently patented
technology directed to maintaining plasma concentrations of the drug in
the therapeutic range with once or twice daily dosage.
SOURCE: sGC Pharma Inc.
For further information:
Robert Bender, Chairman
sGC Pharma Inc.
P: +1. 613. 791. 4465
P: +1. 617. 252. 3443