TORONTO, April 23 /CNW/ - Canadian scientist, Dr. Gordon Keller, and his
team of international researchers have successfully grown human heart
progenitor cells from embryonic stem cells. With this advancement, Dr. Keller,
director of Toronto's McEwen Centre for Regenerative Medicine at the
University Health Network, and his team, have taken a significant step towards
the creation of functioning heart tissue.
"This development means that we can efficiently and accurately make
different types of human heart cells for use in both basic and clinical
research," says Dr. Keller. "The immediate impact of this is significant as we
now have an unlimited supply of these cells to study how they develop, how
they function and how they respond to different drugs. In the future, these
cells may also be very effective in developing new strategies for repairing
damaged hearts, following a heart attack."
The study, a medical first, details supplying embryonic stem cell
cultures with a series of factors that direct them to develop into immature
heart cells, known as heart progenitor cells. These progenitors are able to
make three major cell types found in the human heart - cardiomyocytes,
endothelial cells and vascular smooth muscle cells. These three cell types are
integral to the healthy function of the human heart.
The full study can currently be found in the online version of Nature
publication. Entitled, "Human cardiovascular progenitor cells develop from a
KDR1 embryonic-stem-cell-derived population," the study will also appear in
the print edition in the coming weeks.
About the McEwen Centre for Regenerative Medicine
The McEwen Centre for Regenerative Medicine was established in 2003 with
a generous donation from Rob and Cheryl McEwen. Its mission is to be a
catalyst for regenerative medicine by facilitating collaboration and promoting
research and awareness in the field. The McEwen Centre's ultimate goal is to
accelerate the development of better and more effective treatments for
life-threatening conditions such as heart disease, diabetes, respiratory
disease and spinal cord injury. The McEwen Centre for Regenerative Medicine is
fully affiliated with University Health Network.
About University Health Network
University Health Network consists of Toronto General, Toronto Western
and Princess Margaret Hospitals. The scope of research and complexity of cases
at University Health Network has made it a national and international source
for discovery, education and patient care. It has the largest hospital-based
research program in Canada, with major research in transplantation,
cardiology, neurosciences, oncology, surgical innovation, infectious diseases,
and genomic medicine. University Health Network is a research hospital
affiliated with the University of Toronto.
For further information: For media interviews, please contact: Gehna
Singh, McEwen Centre for Regenerative Medicine, Tel: (416) 340-4800 ext. 6365,
Gehna.singh@uhn.on.ca
