Video B-Roll and VNR Via On-Demand and Satellite - Study uncovers overlooked risk factor that may be key to saving tens of thousands of Canadians from heart attacks and strokes every year

    TORONTO, Nov. 9 /CNW/ - The following B-Roll is available at the listed
times and co-ordinates:

    Live Satellite Coordinates:

    DATE OF FEED No. 1:   November 9, 2008
    TIME OF FEED:         1:30 - 2:00 pm EST
    CO-ORDINATES:         Anik F2 C
                          Transponder 7B
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    DATE OF FEED No. 2:   November 10, 2008
    TIME OF FEED:         10:30 - 11:00 am EST
    CO-ORDINATES:         Anik F2 C
                          Transponder 7B
                          Audio subcarrier 6.2 and 6.8
                          Downlink frequency 3980 vertical

    Broadcast on Demand URL:

    DATE:     November 9, 2008
    TIME:     1:00 pm EST

    http://cnw.pathfireondemand.com/viewpackage.action?packageid=112

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    STORY SUMMARY:

    Results of the JUPITER study were released today at the American Heart
Association and suggest that seemingly healthy Canadians may be saved from
first heart attacks, strokes, or even death if they are screened for elevated
hsC-reactive protein (hsCRP) and successfully lower their cholesterol levels,
even when their cholesterol levels are considered normal.
    Nearly one half of all cardiovascular events occur in patients who are
apparently healthy and who have low or normal levels of low density
lipoprotein cholesterol (LDL-C), a traditional indicator of cardiovascular
risk.

    SHOT LIST:

    Interview with Dr. Jacques Genest, McGill University Health Centre,
    Montreal
    Various b-roll:

    -   people exercising
    -   people eating
    -   Crestor product shots

                               Approx TRT: 1:30

     Visual                          Audio
    -------------------------------------------------------------------------
     b-roll                          VO
     Healthy people on streets       Results released today at the American
                                     Heart Association suggest that seemingly
     Dr. b-roll                      healthy Canadians may be saved from
                                     heart attacks, strokes, or even death if
                                     they are screened for elevated
                                     hsC-reactive protein (hsCRP) and
                                     successfully lower their cholesterol
                                     levels, even when their cholesterol
                                     levels are considered normal.(1)

                                     Dr. Jacque Genest, in Montreal explains.
    -------------------------------------------------------------------------
    Dr. Jacques Genest on cam        Dr. Genest clip:

                                     C-reactive protein belongs to a class of
                                     molecules that are elevated in acute
                                     inflammation. A low level of CRP but
                                     elevated compared to normal, may reflect
                                     chronic inflammation. And that may be
                                     the only risk factor in patients who
                                     have a normal LDL cholesterol and few
                                     other cardiovascular risk factors.
    -------------------------------------------------------------------------
    b-roll of healthy people         VO
                                     Nearly one half of all cardiovascular
                                     events occur in people who are
                                     apparently healthy.(2)
    -------------------------------------------------------------------------
    Product shot                     VO
    And/or insert:                   The trial showed that patients who
    Text over a moving background    received 20mg of CRESTOR(R) daily,
    of key findings, stats, graph,   (rosuvastatin calcium) had reduced
    chart, etc.                      first cardiovascular events by 44%
                                     compared to a placebo.(3) This is the
                                     greatest reduction in risk seen in the
                                     large placebo-controlled statin
                                     trial.(4)
    -------------------------------------------------------------------------
    Dr. on cam                       Dr. Genest clip:

                                     We've known for many years that more
                                     than half of the patients who develop a
                                     myocardial infarction have normal levels
                                     of LDL cholesterol. It's also been known
                                     for a while that C-reactive protein is
                                     elevated in most patients with heart
                                     disease and therefore, JUPITER tested
                                     the hypothesis that treating normal LDL
                                     cholesterol level but high CRP would
                                     have a reduction in cardiovascular end
                                     points.
    -------------------------------------------------------------------------

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    --------------------------------
    (1) Ridker PM. Justification for the Use of Statins in Primary
        Prevention: an Intervention Trial Evaluating Rosuvastatin.
        Presentation at 2008 American Heart Association conference, New
        Orleans
    (2) Ridker PM, Rifai N, Clearfield M, Downs J, Weis SE, Miles JS, Gotto
        A. Measurement of C-reactive Protein for the Targeting of Statin
        Therapy in the Primary Prevention of Acute Coronary Events. N Engl J
        Med 2001;344:1959-1965.
    (3) Ridker PM. Justification for the Use of Statins in Primary
        Prevention: an Intervention Trial Evaluating Rosuvastatin.
        Presentation at 2008 American Heart Association conference, New
        Orleans
    (4) Ridker P, Danielson E, Fonseca FAH, et al. Rosuvastatin to prevent
        vascular events in men and women with elevated C-reactive protein. N
        Engl J Med 2008;359:2195-207

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